ID   G5BDP3_HETGA            Unreviewed;       752 AA.
AC   G5BDP3;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   SubName: Full=Histone-lysine N-methyltransferase EZH1 {ECO:0000313|EMBL:EHB07404.1};
GN   ORFNames=GW7_11421 {ECO:0000313|EMBL:EHB07404.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC   Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB07404.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB07404.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA   Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA   Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of the
RT   naked mole rat.";
RL   Nature 479:223-227(2011).
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DR   EMBL; JH169675; EHB07404.1; -; Genomic_DNA.
DR   AlphaFoldDB; G5BDP3; -.
DR   STRING; 10181.G5BDP3; -.
DR   eggNOG; KOG1079; Eukaryota.
DR   InParanoid; G5BDP3; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0046976; F:histone H3K27 methyltransferase activity; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   InterPro; IPR026489; CXC_dom.
DR   InterPro; IPR045318; EZH1/2-like.
DR   InterPro; IPR048358; EZH1/2_MCSS.
DR   InterPro; IPR021654; EZH1/EZH2.
DR   InterPro; IPR041343; PRC2_HTH_1.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   PANTHER; PTHR45747; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR   PANTHER; PTHR45747:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE EZH1; 1.
DR   Pfam; PF21358; Ezh2_MCSS; 1.
DR   Pfam; PF11616; EZH2_WD-Binding; 1.
DR   Pfam; PF18118; PRC2_HTH_1; 1.
DR   Pfam; PF00856; SET; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS51633; CXC; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000313|EMBL:EHB07404.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   Transferase {ECO:0000313|EMBL:EHB07404.1}.
FT   DOMAIN          531..633
FT                   /note="CXC"
FT                   /evidence="ECO:0000259|PROSITE:PS51633"
FT   REGION          215..243
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          395..447
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          721..745
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        419..442
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        729..744
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   752 AA;  85621 MW;  42F9C03EF548981A CRC64;
     MSSRSLKNQG ASSNPGPLLF YKGEYIKMDI PNPPTSKCTT DWKRKVKSEY MRLRQLRWLQ
     ANMGAKALYV ANFAKVQEKT QILSEEWKQR RVQPVQSMKP VSGHPLLKKC TIKSLFLGFA
     SQHVLMCSLN TVALVPITYS WSPLQQNFMV EDETVLCNIP YMGDEVKEED ETFIEELINN
     YDGKVHGEED MIPGSVLISD AVFLELVDSL NRNSVEEEEG HNDAVNGKQG DGQEDLPVTR
     KRKRHAVEAN RKSFQKQFPN DMIFSAIASM FPESGVPDDM KERKRELTEM LDPNALPPQC
     TLNIDGPNAK SVQREQSLQS FHALFCSRCV KYDCFLHPFH ATPNVYKRKN KESKIEPEPC
     GSDCFLLLEG AKEYAMLHNP RSKCSGRRRR RHHVVSASCP NTSTSTVAER KEWDSDRDTG
     NNWASSSSEA NSRCQTPTKQ KPSPARPHFC VVEAPSEPVE WTGAEESLFL IFHDTYFSNF
     CSTARLLGTK TCKQIFQFAV KESLILKLPT DELMNPSQKK RRKHRLWAAH CRKIQLKKDN
     SARQVYNYQP CDHPDRPCDS TCPCIMTQNF CEKFCQCNPD CQNHFPCCCC KTQCNTKQCP
     CYLAVRKCDP DLCLTCGPSE HSDCKVVSCK NCSIQRGLKK HLLLAPSDAP SWGTFIKESV
     QKNEFISDSC GELISQDEAD RRGKVYDKYT SSFLFNLIND FVVDAARKGN KIRFANHSVN
     PRLLGQSGHG ERRPPHRNLR QEGHPGWRRA LL
//