GenomeNet

Database: UniProt
Entry: G5BDR1_HETGA
LinkDB: G5BDR1_HETGA
Original site: G5BDR1_HETGA 
ID   G5BDR1_HETGA            Unreviewed;       869 AA.
AC   G5BDR1;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   25-OCT-2017, entry version 33.
DE   SubName: Full=Transient receptor potential cation channel subfamily V member 4 {ECO:0000313|EMBL:EHB07422.1};
GN   ORFNames=GW7_12560 {ECO:0000313|EMBL:EHB07422.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Bathyergidae; Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB07422.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB07422.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L.,
RA   Bronson R.T., Buffenstein R., Wang B., Han C., Li Q., Chen L.,
RA   Zhao W., Sunyaev S.R., Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of
RT   the naked mole rat.";
RL   Nature 479:223-227(2011).
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00933551}.
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DR   EMBL; JH169688; EHB07422.1; -; Genomic_DNA.
DR   InParanoid; G5BDR1; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR004729; TRP_channel.
DR   InterPro; IPR024862; TRPV.
DR   InterPro; IPR008347; TRPV1-4_channel.
DR   InterPro; IPR008348; TRPV4_channel.
DR   PANTHER; PTHR10582; PTHR10582; 1.
DR   PANTHER; PTHR10582:SF4; PTHR10582:SF4; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR01768; TRPVRECEPTOR.
DR   PRINTS; PR01769; VRL2RECEPTOR.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   TIGRFAMs; TIGR00870; trp; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023,
KW   ECO:0000256|SAAS:SAAS00933366};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006813};
KW   Ion channel {ECO:0000256|SAAS:SAAS00931870};
KW   Ion transport {ECO:0000256|SAAS:SAAS00929079};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:EHB07422.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   Repeat {ECO:0000256|SAAS:SAAS00931009};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00927442}.
FT   TRANSMEM    468    490       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    510    528       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    549    567       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    573    592       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    613    635       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    692    716       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      236    391       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   REPEAT      236    268       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
SQ   SEQUENCE   869 AA;  98075 MW;  7ABCD55F9C411E8D CRC64;
     MADPGDSPRT GPGELAEPPG DESGTSGGEA FPLSSLANLF EGDEGSSSPS PADAGRHAGQ
     GDGRPNLRMK FQGAFRKGVP NPIDLLESTL YESSVVPGPK KAPMDSLFDY GTYRHHPSDN
     KRWRRKVIEK QPQSPKAPAP QPPPILKVFN RPILFDIVSR GSTADLDGLL PFLLTHKKRL
     TDEEFRGSSW GPRLVQATLL LGNGRNDTIP LLLDIAERTG NMREFINSPF RDIYYRGQTA
     LHIAIERRCK HYVELLVAQG ADVHAQARGR FFQPKDEGGY FYFGELPLSL AACTNQPHIV
     NYLTENPHKK ADMRRQDSRG NTVLHALVAI ADNTRENTKF VTKMYDLLLL KCARLFPDSN
     LEAVLNNDGL SPLMMAAKTG KIGIFQHIIR REVTDEDTRH LSRKFKDWAY GPVYSSLYDL
     SSLDTCGEEA SVLEILVYNS KIENRHEMLA VEPINELLRD KWRKFGAVSF YINVVSYLCA
     MVIFTLTAYY QPLEGTPPYP YRTTGDYLRL AGEVITLFTG VLFFFTNIKD LFMKKCPGVN
     SLFIDGSFQL LYFIYSVLVI VSAALYLAGI EAYLAVMVFA LVLGWMNALY FTRGLKLTGT
     YSIMIQKILF KDLFRFLLVY LLFMIGYASA LVSLLNPCAN MKVCNEDQTN CTVPTYPSCR
     DSDTFSTFLL DLFKLTIGMG DLEMLSSTKY PVVFIILLVT YIILTFVLLL NMLIALMGET
     VGQVSKESKH IWKLQWATTI LDIERSFPVF LRKAFRSGEM VTVGKSSDGT PDRRWCFRVD
     EVNWSHWNQN LGIINEDPGK SDTYQYYGFS HTVGRLRRDR WSSVVPRVVE LNKNSSPDEV
     VVPLDNRENP SCDSQQQSYP KWRTDDDAL
//
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