ID G5BEH3_HETGA Unreviewed; 485 AA.
AC G5BEH3;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Transcription factor SOX-5 {ECO:0000313|EMBL:EHB07684.1};
GN ORFNames=GW7_05670 {ECO:0000313|EMBL:EHB07684.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB07684.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB07684.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; JH169815; EHB07684.1; -; Genomic_DNA.
DR AlphaFoldDB; G5BEH3; -.
DR STRING; 10181.G5BEH3; -.
DR eggNOG; KOG0528; Eukaryota.
DR InParanoid; G5BEH3; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd22042; HMG-box_EGL13-like; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR PANTHER; PTHR45789; FI18025P1; 1.
DR PANTHER; PTHR45789:SF3; TRANSCRIPTION FACTOR SOX-5; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00267};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT DOMAIN 278..346
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 278..346
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 81..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 436..485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 175..236
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 88..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..472
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 485 AA; 52949 MW; B55EAF8AAE6BEF6F CRC64;
MIPVFPPDQR TLAAAAQQGF LLPPGFSYKA GCSDPYPVQL IPTTMAAAAA ATPGLGPLQL
QQLYAAQLAA MQVSPGGKLP GIPQGNLGAA VSPTSIHTDK STNSPPPKSK DEVAQPLNLS
AKPKTSDGKS PTSPTSPHMP ALRINSGAGP LKASVPATLA SPSARVSTIG YLNDHDAVSK
AIQEARQMKE QLRREQQVLD GKVAVVNSLG LNNCRTEKEK TTLESLTQQL AVKQNEEGKF
SHAMMDFNMS GDSDGSAGVS ESRIYRESRG RGSNEPHIKR PMNAFMVWAK DERRKILQAF
PDMHNSNISK ILGSRWKAMT NLEKQPYYEE QARLSKQHLE KYPDYKYKPR PKRTCLVDGK
KLRIGEYKAI MRNRRQEMRQ YFNVGQQAQI PMATAGVVYP GAIAMAGMPS PHLPSEHSSV
SSSPEPGMPV IQSTYGVKGE EPHIKEEIQA EDINGEIYDE YDEEEDDPDV DYGSDSENHI
TGQAN
//
