ID G5BFD9_HETGA Unreviewed; 690 AA.
AC G5BFD9;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Zinc transporter ZIP12 {ECO:0000256|ARBA:ARBA00040591};
DE AltName: Full=Solute carrier family 39 member 12 {ECO:0000256|ARBA:ARBA00042541};
DE AltName: Full=Zrt- and Irt-like protein 12 {ECO:0000256|ARBA:ARBA00042971};
GN ORFNames=GW7_20294 {ECO:0000313|EMBL:EHB08000.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB08000.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB08000.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351,
CC ChEBI:CHEBI:29105; Evidence={ECO:0000256|ARBA:ARBA00034634};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000256|ARBA:ARBA00006939}.
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DR EMBL; JH169933; EHB08000.1; -; Genomic_DNA.
DR AlphaFoldDB; G5BFD9; -.
DR STRING; 10181.G5BFD9; -.
DR eggNOG; KOG2693; Eukaryota.
DR InParanoid; G5BFD9; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR003689; ZIP.
DR InterPro; IPR049406; ZIP4_12_EF-hand.
DR InterPro; IPR041137; ZIP4_N.
DR PANTHER; PTHR12191; SOLUTE CARRIER FAMILY 39; 1.
DR PANTHER; PTHR12191:SF4; ZINC TRANSPORTER ZIP12; 1.
DR Pfam; PF21116; EF-hand_Zip; 1.
DR Pfam; PF02535; Zip; 1.
DR Pfam; PF18292; ZIP4_domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..690
FT /note="Zinc transporter ZIP12"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003474358"
FT TRANSMEM 366..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 402..424
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 444..468
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 535..553
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 601..619
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 631..649
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 661..684
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 63..221
FT /note="Zinc transporter ZIP4 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18292"
FT DOMAIN 230..345
FT /note="Zinc transporter ZIP4/12 EF-hand"
FT /evidence="ECO:0000259|Pfam:PF21116"
FT REGION 493..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 690 AA; 76044 MW; 2C97A6E8E37FF4FF CRC64;
MSLWTKLLVY GVPLFLLVSF VPCTATDTPS SQDSLGTEKQ GQLAEILRIL SADDHPPLNH
SRSLIATLLE KTGCPRTHGL QGGCHLCFEP DALLLIAGGD LEEQLPEEVV QRVSLLLLYY
IIHQEEICSS KLNMSNKDYK FYLHSLLSLR QDEDSYFLSQ NETEDILALT RRHFDTSRSE
CMETKMLQRK SGILSTDGAD ENTLPRLAAT IIALSLQGVC LGQRNSPSSD YFTEYIFRLL
NSTNALHLSE LEQLFNILWT KSTCNKKDVI HQPQRKQGHI KVHDWGYPNL SISMDKESDD
GPNSWDQTCF SARQLVEIFL QNSLSVISKE DFKQISPGII QQLLSCSCQL PMDQQAKHLP
TTLQKYGYGT AAVALLTLGS MLGSTLVLFH SCEENYDIVL QLFMGFAVGT LSGDALLHLI
PQVLGLHRQE APEFGHFHES KGHIWKLLGL IGGIHGFFLI EKCFALLVSP NAKQGPSLAN
GHVGHSHHLA LNPEVSEQPG RGKSASAIQL KGPEDSQAGE ISVASMTTSN RKCKAISLLA
VMILVGDSLH NFADGLVLGA AFSSSSELGV TTTIAILCHE IPHEMGDFAV LLSSGLSVKT
AILMNFISAL TAFAGLYIGL SVSADPCIQD WLLTVTAGMF LYLSLVEMLP EMTHVQTRRP
WMMFLLQNIG LILGWLSLLL LAIYEQNIKI
//
