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Database: UniProt
Entry: G5BG74_HETGA
LinkDB: G5BG74_HETGA
Original site: G5BG74_HETGA 
ID   G5BG74_HETGA            Unreviewed;      1480 AA.
AC   G5BG74;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   24-JAN-2024, entry version 60.
DE   SubName: Full=Tyrosine-protein kinase BAZ1B {ECO:0000313|EMBL:EHB08285.1};
GN   ORFNames=GW7_08892 {ECO:0000313|EMBL:EHB08285.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC   Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB08285.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB08285.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA   Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA   Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of the
RT   naked mole rat.";
RL   Nature 479:223-227(2011).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00475}.
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DR   EMBL; JH170081; EHB08285.1; -; Genomic_DNA.
DR   RefSeq; XP_004840127.1; XM_004840070.1.
DR   STRING; 10181.G5BG74; -.
DR   GeneID; 101708143; -.
DR   KEGG; hgl:101708143; -.
DR   CTD; 9031; -.
DR   eggNOG; KOG1245; Eukaryota.
DR   InParanoid; G5BG74; -.
DR   OrthoDB; 5490909at2759; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0090535; C:WICH complex; IEA:InterPro.
DR   GO; GO:0140801; F:histone H2AXY142 kinase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd05505; Bromo_WSTF_like; 1.
DR   CDD; cd15628; PHD_BAZ1B; 1.
DR   Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR047174; BAZ1B.
DR   InterPro; IPR037375; BAZ1B_Bromo.
DR   InterPro; IPR047256; BAZ1B_PHD.
DR   InterPro; IPR001487; Bromodomain.
DR   InterPro; IPR036427; Bromodomain-like_sf.
DR   InterPro; IPR018359; Bromodomain_CS.
DR   InterPro; IPR018501; DDT_dom.
DR   InterPro; IPR028942; WHIM1_dom.
DR   InterPro; IPR028941; WHIM2_dom.
DR   InterPro; IPR013136; WSTF_Acf1_Cbp146.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR46802; TYROSINE-PROTEIN KINASE BAZ1B; 1.
DR   PANTHER; PTHR46802:SF1; TYROSINE-PROTEIN KINASE BAZ1B; 1.
DR   Pfam; PF00439; Bromodomain; 1.
DR   Pfam; PF00628; PHD; 1.
DR   Pfam; PF10537; WAC_Acf1_DNA_bd; 1.
DR   Pfam; PF15612; WHIM1; 1.
DR   Pfam; PF15613; WSD; 1.
DR   PRINTS; PR00503; BROMODOMAIN.
DR   SMART; SM00297; BROMO; 1.
DR   SMART; SM00571; DDT; 1.
DR   SMART; SM00249; PHD; 1.
DR   SUPFAM; SSF47370; Bromodomain; 1.
DR   SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR   PROSITE; PS00633; BROMODOMAIN_1; 1.
DR   PROSITE; PS50014; BROMODOMAIN_2; 1.
DR   PROSITE; PS50827; DDT; 1.
DR   PROSITE; PS51136; WAC; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
DR   PROSITE; PS50016; ZF_PHD_2; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW   ProRule:PRU00035};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Kinase {ECO:0000313|EMBL:EHB08285.1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00475}; Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Transferase {ECO:0000313|EMBL:EHB08285.1};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00175}.
FT   DOMAIN          20..126
FT                   /note="WAC"
FT                   /evidence="ECO:0000259|PROSITE:PS51136"
FT   DOMAIN          604..668
FT                   /note="DDT"
FT                   /evidence="ECO:0000259|PROSITE:PS50827"
FT   DOMAIN          1182..1232
FT                   /note="PHD-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50016"
FT   DOMAIN          1185..1230
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   DOMAIN          1353..1423
FT                   /note="Bromo"
FT                   /evidence="ECO:0000259|PROSITE:PS50014"
FT   REGION          145..210
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          302..333
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          381..433
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          447..470
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          787..820
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1118..1138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1235..1274
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1288..1323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1450..1480
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          537..579
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        168..210
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        411..426
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1248..1272
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1480 AA;  170866 MW;  BA05579DE93881CA CRC64;
     MAPLLGRKPF PLVKPLPGEE PLFTIPHTQE AFRTREEYEA RLERYSERIW TCKSTGSSQL
     THKEAWEEEQ EVAELLKEEF PTWYEKLVLE MVHHNTASLE KLVDTAWLEI MTKYAVGEEC
     DFEVGKEKML KVKIVKIHPL EKVDEEATEK KSDGACDSPS SDKENSSQMA QDHQKKEAVV
     KEDEGRREII NDRARRSPRK LPTSLKKGER KWAPPKFLPH KYDVKLQNED KIISNVPADS
     LIRTERPPNK EILRYFIRHN ALRAGAGENA PWVVEDELVK KYSLPSKFSD FLLDPYKYMT
     LNPSTKRKNT GSPDRKPSKK SKTDNSSLSS PLNPKLWCHV HLKKSLNGSP LKMKNSKNSK
     SPEEHLEEVM KMMSPNKLHA NFHIPKRGPA AKKPGKHSDK PLKAKGRSKG ILNGQKSTGS
     SKSPKKGLKT PKTKMKQMTL LDMAKGTQKM ARAPRNSGGT PRSSSKPHKH LPPAALHLIA
     YYKENKDRED KKSALSCVIS KTARLLSSED RARLPEELRT IVQKRYELLE HRKRWASMSE
     EQRKEYLKKK RQELKEKLKE KAKERRQKEM LEKLEKQKRY EDQELAGKNL PTFRLVDTPE
     GLPNTLFGDV ALVVEFLSCY SGLLLPDAQY PITAVSLMEA LSADKGGFLY LNRVLVILLQ
     TLLQDEIAED YGELGMKLSE IPLTLHSVSE LVRLCLRRSD AQEESESSDT DDKDSAPFED
     NEVQDEFLEK LETSEFFELT SEEKLQILTA LCHRILMTYS VQDHMETRQQ MSAELWKERL
     AVLKEENDKK RAEKQKRKEM EARSKENGKE ENGLGKTDRK KEIVKFEPQV DMEAEDMISA
     VKSRRLLALQ AKREREIQER EMKVKLEREA EEERIRKHKA AAEKAFQEGI ARAKLVMRRT
     PIGTDRNHNR YWLFSDEVPG LFIEKGWAHD SIDYRFNHHR KDHADSSGED YCPRSKKANL
     GKNASMNTHR SALEIAVETT IPKQGQNLWF LCDSQKELDD LLNCLHPQGI RESQLKERLE
     KRYQDIIHSI HLARKPNLGL KCCDGNQELL NFLRSDLIEV ATRLQKGGLG YVEETSEFEA
     RVISLEKLKD FGECVIALQA SVIKKFLQGF MAPKQKRRKV QSEDSAKTEE VDEEKKMAEE
     EKVASALEKW KTAIREAQTF SRMHVLLGML DACIKWDMSA ENARCKVCRK KGEDDKLILC
     DECNKAFHLF CLRPALYEVP DGEWQCPACQ PATARRNSRG RNYTEESASE DSEDDESDSE
     EEEEEEEEEE DYEVAGLRLR PRKIIRGKQI VIPPASRPGR RPGKKPHPPQ RSQQKASPVD
     DVEVDELVLQ TKRSSRRQSL ELQKCEEILH KIVKYRFSWP FREPVTRDEA EDYYDVITQP
     MDFQTMQNKC SCGNYRSVQE FLTDMKQVFT NAELYNCRGS HVLNCTVKTE QCLVALLHKH
     LPGHPYVRRK RKKFPDRLAD DEVDSDPEPV GQSRGRRQKK
//
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