ID   G5BGC2_HETGA            Unreviewed;       257 AA.
AC   G5BGC2;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE            EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
DE   Flags: Fragment;
GN   ORFNames=GW7_11375 {ECO:0000313|EMBL:EHB08333.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC   Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB08333.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB08333.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA   Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA   Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of the
RT   naked mole rat.";
RL   Nature 479:223-227(2011).
CC   -!- SIMILARITY: Belongs to the ADP-ribosyl cyclase family.
CC       {ECO:0000256|ARBA:ARBA00005406}.
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DR   EMBL; JH170117; EHB08333.1; -; Genomic_DNA.
DR   AlphaFoldDB; G5BGC2; -.
DR   STRING; 10181.G5BGC2; -.
DR   eggNOG; ENOG502S1HV; Eukaryota.
DR   InParanoid; G5BGC2; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProt.
DR   GO; GO:0050135; F:NAD(P)+ nucleosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0061809; F:NAD+ nucleotidase, cyclic ADP-ribose generating; IEA:UniProtKB-EC.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   CDD; cd04759; Rib_hydrolase; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR003193; ADP-ribosyl_cyclase.
DR   PANTHER; PTHR10912; ADP-RIBOSYL CYCLASE; 1.
DR   PANTHER; PTHR10912:SF4; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE 2; 1.
DR   Pfam; PF02267; Rib_hydrolayse; 1.
DR   SUPFAM; SSF52309; N-(deoxy)ribosyltransferase-like; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:EHB08333.1"
SQ   SEQUENCE   257 AA;  28606 MW;  CC407A0A5AF1828A CRC64;
     RDKNCTAIWE AFRVVLDKDP CSVLPSDYDL FINLSRHPIP RDKSLFWENN HLLVAGYSEN
     TRRFMPLCDV LYGRVGDFLS WCRQKNASGL DYQSCPTSED CENNAVDSYW KRASMQYSRD
     SSGVIYVMLN GSEPKGAYPI KGFFADFEIP YLQKDKVTQI EIWVMHEIGG PNVESCGEGS
     VKILEDRLEA LGFRHSCVND HTPVKLLMCV DHSTHPDCAF ASSATAAAER GAPPRSTAHS
     STLLAALLVA LASGSQM
//