ID G5BI42_HETGA Unreviewed; 1394 AA.
AC G5BI42;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Histone-lysine N-methyltransferase MLL5 {ECO:0000313|EMBL:EHB08953.1};
DE Flags: Fragment;
GN ORFNames=GW7_03887 {ECO:0000313|EMBL:EHB08953.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB08953.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB08953.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
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DR EMBL; JH170409; EHB08953.1; -; Genomic_DNA.
DR STRING; 10181.G5BI42; -.
DR eggNOG; KOG1844; Eukaryota.
DR InParanoid; G5BI42; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd15550; PHD_MLL5; 1.
DR CDD; cd19182; SET_KMT2E; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR044434; KMT2E_SET.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46462:SF2; INACTIVE HISTONE-LYSINE N-METHYLTRANSFERASE 2E; 1.
DR PANTHER; PTHR46462; UPSET, ISOFORM A; 1.
DR Pfam; PF20826; PHD_5; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00249; PHD; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000313|EMBL:EHB08953.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Transferase {ECO:0000313|EMBL:EHB08953.1};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 117..165
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 329..446
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 1213..1301
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 216..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 471..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 621..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 884..919
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1000..1026
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1189..1394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 573..610
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 225..256
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 481..502
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..517
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 644..666
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1009..1023
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1242..1261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1266..1281
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1284..1306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1326..1354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1355..1373
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHB08953.1"
SQ SEQUENCE 1394 AA; 154237 MW; E9E8D7A64A364EB4 CRC64;
MSIVIPLGVD TAEASYLEMA AGSGKSVEAS PVVVEKSNSY PHQLYTSSSH HSHSYIGLPY
ADHNYGARPP PTPPASPPPS VLISKNEVGI FTTPNFDETS SATTISTSED GSYGTDVTRC
ICGFTHDDGY MICCDKCSVW QHIDCMGINR QHIPDTYLCE RCQPRSLDKE RAVLLQRRKR
ENMSDGDTSA TESGDEVPVG LYTAFQHTPT SITLTASRVS KVNDKRRRKS GEKEQNISKC
KKAFREGSRK SSRVKGSAPE IDPSSDGSNF GWETKIKAWM DRYEEANNNQ YSEGIQREAQ
RIALRLGNGS DKKDMNKAEL NINNLLFKPP VESHIQKNKK ILKSAKDLPP DALIIEYRGK
FMLREQFEAN GYFFKRPYPF VLFYSKFHGL EMCVDARTFG NEARFIRRSC TPNAEVRHEI
EEGTIHLYIY SIQSIPKGTE ITIAFDFDYG NCKYKVDCAC LKENPECPVL KRSSESTENI
HSGYETRRKK GRKDKDISKE KDTQNQNMTV DSEGTTNKIK SSETKQRKLS PLRLSVSNNQ
EPDFIDDIEE KTPISNEVEM ESEEQIAERK RKMTREERKM EAILQAFARL EKREKRREQA
LERISTARTE VKAECRDTQV ASDAEVTQEQ AKEEAANKPA PARVNRAKQR KSFSRSRTHI
GQQRRRHRTV SMCSDVQPPS PDVEITTQPH EVENPVLVIE PDTETAVAEI VTETEAPALH
KCPLKYPKTK KHLVSEWLSE KNEKTGKPSE SLSERPLRIT TDPEVLATQL NSLPGLTYSP
HVYSTPKHYI RFTSPFLSEK RRRKEPTDNA SGSCKKRWLK QALEEENSAI LHRFNSPCQE
RSRSPIVNGE NKSPLLLNDS CSLPDLTTPL KKRRLYQLLD SVYSESSTPT PSPYATPTHA
DIAPTDPAFA TPPRVKADDE TCRNGYKPIY SPVTPVTPGT PGNTMHFENI SSPESSPEIK
RRTYSQEGYE RSATLLTLGP FRNSSVTELG LQEIKTIGYA SPRSRTEASR PGLGEKEPAT
DLHPGLDTGE PAALLKTMEA PAHDRPEPAV ALDSSHPGRA ALYPSWVKSP DRAGVSFSVN
SNLRDLTPSH QLEVGGGFRV SESKCLTQED SRAVFLEAAV FCPAEDGLLS GFGRTVTDAL
MDGSCTPQNP PQKKKVSLLE YRKRQREAQK SGSKADGFPL VSALPGAGGS LSSSDCAPGS
DSGEQAENGA RLPPPTPVAA LSAGEEMGAD CPVRDATASA SEKSEPEVQW TASTSVEQVR
ERSYQRALLL SDHRKDKDSG GESPCVSCSP SHVQSSPSSH SNHIPQLQPK GLGPLSELVE
DPDPENPEPT TTNECPSPDT SQNSCKSPSK MNKPSSPGPG TPAPQPQHGK PLCKPEPPWE
AAEAELSAAP RTEL
//
