ID G5BKK7_HETGA Unreviewed; 291 AA.
AC G5BKK7;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Syntaxin-6 {ECO:0000256|ARBA:ARBA00044124};
GN ORFNames=GW7_08681 {ECO:0000313|EMBL:EHB09818.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB09818.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB09818.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00037867}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00037867}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004409}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004409}. Golgi apparatus, trans-Golgi network
CC membrane {ECO:0000256|ARBA:ARBA00037801}; Single-pass type IV membrane
CC protein {ECO:0000256|ARBA:ARBA00037801}. Membrane
CC {ECO:0000256|ARBA:ARBA00004211}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004211}. Recycling endosome membrane
CC {ECO:0000256|ARBA:ARBA00043941}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00043941}.
CC -!- SIMILARITY: Belongs to the syntaxin family.
CC {ECO:0000256|ARBA:ARBA00009063}.
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DR EMBL; JH170762; EHB09818.1; -; Genomic_DNA.
DR AlphaFoldDB; G5BKK7; -.
DR STRING; 10181.G5BKK7; -.
DR eggNOG; KOG3202; Eukaryota.
DR InParanoid; G5BKK7; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IEA:UniProt.
DR GO; GO:0005484; F:SNAP receptor activity; IEA:InterPro.
DR GO; GO:0048193; P:Golgi vesicle transport; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd15851; SNARE_Syntaxin6; 1.
DR Gene3D; 1.20.5.110; -; 1.
DR Gene3D; 1.20.58.90; -; 1.
DR InterPro; IPR010989; SNARE.
DR InterPro; IPR045242; Syntaxin.
DR InterPro; IPR015260; Syntaxin-6_N.
DR InterPro; IPR006012; Syntaxin/epimorphin_CS.
DR InterPro; IPR000727; T_SNARE_dom.
DR PANTHER; PTHR19957; SYNTAXIN; 1.
DR PANTHER; PTHR19957:SF104; SYNTAXIN-6; 1.
DR Pfam; PF05739; SNARE; 1.
DR Pfam; PF09177; Syntaxin-6_N; 1.
DR SMART; SM00397; t_SNARE; 1.
DR SUPFAM; SSF58038; SNARE fusion complex; 1.
DR SUPFAM; SSF47661; t-snare proteins; 1.
DR PROSITE; PS00914; SYNTAXIN; 1.
DR PROSITE; PS50192; T_SNARE; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 271..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 199..261
FT /note="T-SNARE coiled-coil homology"
FT /evidence="ECO:0000259|PROSITE:PS50192"
SQ SEQUENCE 291 AA; 32852 MW; 364AAEF03350A138 CRC64;
MVAEVEQRIS FVIGCGRGPR GRGQVDGHAA RGLPLGRRRS PGFGPREVQK AVNTAQGLFQ
RWTELLQDPS AATREEIDWT TNELRNNLRS IEWDLEDLDE TINILFFEAN PRKFNLDATE
LSIRKAFITS TRQVVRDMKD QMSTSSVQAL AERKNRQALL GDSGSQNWGT GTTDQYGRLD
RELELANSHF IEEQQAQQQL IVEQQDEQLE LVSGSIGVLK NMSQRIGGEL EEQAVMLDDF
SHELESTQSR LDNVMKKLAK VSHMTSDGRQ WCAIAILFVV LLVVLILFLV L
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