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Database: UniProt
Entry: G5BKK9_HETGA
LinkDB: G5BKK9_HETGA
Original site: G5BKK9_HETGA 
ID   G5BKK9_HETGA            Unreviewed;      2317 AA.
AC   G5BKK9;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   27-SEP-2017, entry version 27.
DE   RecName: Full=Voltage-dependent R-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   ORFNames=GW7_08683 {ECO:0000313|EMBL:EHB09820.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Bathyergidae; Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB09820.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB09820.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L.,
RA   Bronson R.T., Buffenstein R., Wang B., Han C., Li Q., Chen L.,
RA   Zhao W., Sunyaev S.R., Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of
RT   the naked mole rat.";
RL   Nature 479:223-227(2011).
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1E
CC       gives rise to R-type calcium currents. R-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA).
CC       They are however insensitive to dihydropyridines (DHP), omega-
CC       conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega-
CC       Aga-IVA). Calcium channels containing alpha-1E subunit could be
CC       involved in the modulation of firing patterns of neurons which is
CC       important for information processing.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; JH170762; EHB09820.1; -; Genomic_DNA.
DR   InParanoid; G5BKK9; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005449; VDCC_R_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF253; PTHR10037:SF253; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01633; RVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006813};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    140    161       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    173    193       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    232    254       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    306    327       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    339    361       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    488    508       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    514    532       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    614    636       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    691    714       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1164   1183       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1236   1253       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1297   1319       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1409   1434       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1490   1508       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1520   1543       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1588   1605       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1611   1633       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1703   1727       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1743   1778       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      710    737       {ECO:0000256|SAM:Coils}.
FT   COILED     1109   1136       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2317 AA;  261840 MW;  CD442491430FEE3D CRC64;
     MARFGEAVVG RPGSGDGDSD QSRNRQGTPV PASGPAAAYK QSKAQRARTM ALYNPIPVRQ
     NCFTVNRSLF IFGEDNIVRK YAKKLIDWPV NLFLNFSFPT PFEYMILATI IANCIVLALE
     QHLPEDDKTP MSRRLEKTEP YFIGIFCFEA GIKIVALGFI FHKGSYLRNG WNVMDFIVVL
     SGILATAGTH FNTHVDLRTL RAVRVLRPLK LVSGIPSLQI VLKSIMKAMV PLLQIGLLLF
     FAILMFAIIG LEFYSGKLHR ACFMNNSGIL EGFDPPHPCG VQGCPAGYEC KDWIGPNDGI
     TQFDNILFAV LTVFQCITME GWTTVLYNTN DALGATWNWL YFIPLIIIGS FFVLNLVLGV
     LSGEFAKERE RVENRRAFMK LRRQQQIERE LNGYRAWIDK AEEVMLAEEN KNAGTSALEV
     LRRATIKRSR TEAMTRDSSD EHCVDISSVG TPLARASIKS TKVDGASYFR HKERLLRISI
     RHMVKSQVFY WIVLSLVALN TACVAIVHHN QPQWLTHLLY YAEFLFLGLF LLEMSLKMYG
     MGPRLYFHSS FNCFDFGVTV GSIFEVVWAI FRPGTSFGIS VLRALRLLRI FKITKYWASL
     RNLVVSLMSS MKSIISLLFL LFLFIVVFAL LGMQLFGGRF NFNDGTPSAN FDTFPAAIMT
     VFQILTGEDW NEVMYNGIRS QGGVSSGMWS AIYFIVLTLF GNYTLLNVFL AIAVDNLANA
     QELTKDEQEE EEAFNQKHAL QKAKEVSPMS APNMPSIERD RRRRHHMSMW EPRSSHLRER
     RRRHHMSVWE QRTSQLRRHM QMSSQEALNK EEAPPMNPLN PLNPLSPLNP LNAHPSLYRR
     SRPIEGLALG LGLEKCEEER ISRGGSLKGD GGDLTGALDN QRSPLSLGKR EPPWLARPCH
     GNCDPTQQEA GGGETVVTFE DRARHRQSQR RSRHRRVRTE GKESASASRS RSASQERSLD
     EVGAPEGEKD HEFRGSHGGK EPTIHEEEQS QDLRRTNSLM EPRGSGLAGA LDEPDTPLVL
     PQPELEVGKD TVLAEQEPEG SSEQALLGDV QLDVGRGISQ SEPDLSCITA STDKAATEST
     SVTVAIPEVG PLVDSTVVHI SNKTDGEASP LKEAEIKEEE NEVEKKKQKK EKRETGKAMV
     PHSSMFIFST TNPIRRACHY IVNLRYFEMC ILLVIAASSI ALAAEDPVLT NSERNKVLRY
     FDYVFTGVFT FEMVIKMIDQ GLILQDGSYF RDLWNILDFV VVVGALVAFA LATNKGRDIK
     TIKSLRVLRV LRPLKTIKRL PKLKAVFDCV VTSLKNVFNI LIVYKLFMFI FAVIAVQLFK
     GKFFYCTDSS KDTEKECIGN YVDHEKNKME VKGREWKRHE FHYDNIIWAL LTLFTVSTGE
     GWPQVLQHSV DVTEEDRGPS RSNRMEMSIF YVVYFVVFPF FFVNIFVALI IITFQEQGDK
     MMEECSLEKN ERACIDFAIS AKPLTRYMPQ NRHTFQYRVW HFVVSPSFEY TIMAMIALNT
     VVLMMKYYSA PCTYELALKY LNIAFTMVFS LECVLKVIAF GFLNYFRDTW NIFDFITVIG
     SITEIILTDS KLVNTSGFNM SFLKLXRLIL LRQGYTIRIL LWTFVQSFKA LPYVCLLIAM
     LFFIYAIIGM QVFGNIKLDE ESHINRHNNF RSFFGSLMLL FRSATGEAWQ EIMLSCLGEK
     GCEPDTTAPS GQNENERCGT DLAYVYFVSF IFFCSFLMLN LFVAVIMDNF EYLTRDSSIL
     GPHHLDEFVR VWAEYDRAAC GRIHYTEMYE MLTLMSPPLG LGKRCPSKVA YKRLVLMNMP
     VAEDMTVHFT STLMALIRTA LDIKIAKGGA DRQQLDSELQ KETLAIWPHL SQKMLDLLVP
     MPKASDLTVG KIYAAMMIMD YYKQSKVKKQ RQQLEEQKNA PMFQRMEPSS LPQEIIANAK
     ALPYLQQDPV SGLSGRSGYP SMSPLSPQEI FQLACMDPAD DGQFQEQQSL EPEVSELKSV
     QSSNYGIYLP SDTQEHAGSG RASSMPRLTM DPQVVTDPSS MRRSFSTIRD KRSNSSWLEE
     FSMERSSENT YKSRRRSYHS SLRLSAHRLN SDSGHKSDTH RSGGRERGRS KERKHLLSPD
     VSRCNSEERG TQADWDSPER HQSRSPSEGR SQTPNRQGTG SLSESSIPSV SDTSTPRRSR
     RQLPPVPPKP RPLLSYSSLM RHAGSISPPA DGSEGGSPLT SQALESNNAC LTESSNSPHP
     QQGQHFSPQR YISEPYLALH EDSHASDCGE EETLTFEAAV ATSLGRSNTI GSAPPLRHSW
     QMPNGHYRRR RRGGPGPGTM CGAVSDLLSD TEEDDKC
//
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