ID G5BM73_HETGA Unreviewed; 3132 AA.
AC G5BM73;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Abnormal spindle-like microcephaly-associated protein-like protein {ECO:0000313|EMBL:EHB10384.1};
GN ORFNames=GW7_21548 {ECO:0000313|EMBL:EHB10384.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB10384.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB10384.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; JH170987; EHB10384.1; -; Genomic_DNA.
DR STRING; 10181.G5BM73; -.
DR InParanoid; G5BM73; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR CDD; cd21223; CH_ASPM_rpt1; 1.
DR CDD; cd21224; CH_ASPM_rpt2; 1.
DR Gene3D; 1.20.5.190; -; 26.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR031549; ASH.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22706:SF1; ABNORMAL SPINDLE-LIKE MICROCEPHALY-ASSOCIATED PROTEIN ISOFORM X1; 1.
DR PANTHER; PTHR22706; UNCHARACTERIZED; 1.
DR Pfam; PF15780; ASH; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 28.
DR SMART; SM00033; CH; 2.
DR SMART; SM00015; IQ; 52.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 14.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50096; IQ; 30.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT DOMAIN 908..1044
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1098..1249
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
SQ SEQUENCE 3132 AA; 368176 MW; 2B9CF70A683B9520 CRC64;
MSLAIPAVRR KDVEIRELSP AERRPRAEWE AAEEPASPAV LSLSHFCRSP FLSFGDVRLG
VSRTLPLVLH NPNAEVAEVE VAHLRAAELG FSVCPRRCVL QPKEKIVVSV NWTPLKEGRV
RETVTFLVNN VVKHQAILLG NAEERKKKKK SLWATVNKTV SASSTHNKKI SNTQNINKTF
SVSLKVDRVR SPLQACENLA MSEGCAPTEN SSLTLEENKI PISPIRPAFK ECHVETCLPF
SVRRSTTYSS LHASENGEQI QVEGAIISKD FNFDEKVITE TSFNSINTSG ESEVNTNIIL
TPSCSSPLNI IQTQRNFLNP YSFVNNTPAS NDVGLMTCLL SDTLAKDNLK SVHLESETVH
EVYQTVLSPD SFVNGNYGLK QNLESESVNP ILSPSQFVKD NMPHISIAQE TCKDSPLSNE
NSQFPQDRRK SEVFPCVPEC QGSKTSGVIP EELNPEAMKS DYLFTKQSHP KFSAGEQPKR
RPILSATVTK RKPAYAGEKQ TEINKSKAKR CLNSTVGECE KVIDNQKEKA FRSYLPIIDP
ILTTPQNYKS GTTPSTSLVA RKRKSDRNME DGNVKAVTEH TEVHKVKRIH FSPPESNLST
IRTKKMTTPI SKCINSREKL SLKKRTDSSG FKTPTYKTTK RTKSIVAVAQ SNLTFIKPIK
TGMCIPRHPM PFAAKNMFYD ERWKEKQEQG FTWWLNFILT PDDFTVKTNI SEVNAATVLL
GVENQHKISV LRAPTKDEMS LRAYTARCRL NKLRRTACHL FTSEKMVRAI KKLEIEIEAK
RLIVRKDRHL WKDVGERQKV LNWLLSYNPL WLRIGLETVY GELIPLEDSS DITGLAVFIL
NRLLWNPDIA SEYRHPSVPH LYRDGHEEAL SKFTLKKLLL LVCFLDHAKI SRLIDHDPCL
FCKDAEFKAS KEILLAFSRD FLSGEGDLSR HLSLLGLPVS HVQTPFDEFD FAVTNLAVDL
QCGVRLVRTM ELLTQNWDLS KKLRIPAISR LQKMHNVDLV LQILKSRGIQ LSDEHGNTIL
SKDIVDRHRE KTLGLLWKIA FAFQVEISLN LDQLKEEINF LKHTHSIKKT MSGLSCHSDA
VINKKKDERQ NSVLDHYSES VKLLMDWVNA VCAFYNKKVE NFTVSFSDGR VLCYLLHHYH
PCYVPFDAVC QRTTQTVECT QTGSVVLNSS SESDDSSLDM SLKALNHENN SELHKELLEN
EKKNFHLVRS AVRDLGGIPA MIHHSDMSNT IPDEKVVIMY LSFLCARLLD LRKEIRAARL
IQTTWRKYKL KKDLKHHQER DKAARIIQSA VINFLTKQRL KKEANATLII QKYWRRILAQ
RKLLMLRKEK LEKIQNKSAS VIQGYWRRYC TRKRFLKLKY YSVILQSRIR MIIAVTSYKR
CRWATVTIQR HWRAYLRRKK DQERYEILKS SVLIIQSRFR RWKQHKMQLQ TKAVIILQRA
FREWHFRKAK EKSAIVIQSW YRMHKELQKY IYIKSCVVII QRRFRCHQAQ KLYKRKRESI
LTIQKYYRAY LKGKMERTNY LQKRAAAIRL QAAFRRMKAH NLQRQIRAAC VLQSYWRMRR
DKFQFLSLKK SVIKLQAHVR KHQQLQKYKK MKKAAIIIQT HFQAYISARE VLASYQKTRS
AVIVLQSAYR GMQARKMFHH ILTSVIKIQS YYRAYTSRKK FLSLKSCTIK FQSIVRMRQV
RRQYLCLREA ALFIQQWYRS QKMAARKRKE YLQMRESCIT LQAFFRGYLV RKQMRLQRKA
AISLQSYFRM RKMRQHYLKT YKAITVIQNY YRAYKAQVNQ RKNFLQVKRA ATCLQAAYRG
YKVRQIIKQQ SIAALKIQTA FRGYSKRMKY HSVLQSTVKI QRWYRVHKIV GDMRRDFLKT
RAAVISLQSA YRGWKVRKQI QKEHQAAVKI QSVFRMIKAQ RQFRLLKTAT LVIQQHLRAL
TAGRKQRMEY IKLRHAVVVL QSTWKGKTLR RQIEKQHNCA VIIQSYFRMH VQQKKWKTMK
KAVLLIQMYY RAYSVGREEH HLYLKKKAAI VTLQSAYRGM TVRKRIKNCN KAAVTIQSKY
RAYRTQKKYV TYRVSAVIIQ RWYRDIKNGN HQRKEYLNLK KAAIKIQAVY RGIRVRRHIQ
HLHMAATFIK AMFKMHQSRV RYHTMRRAAV VIQRRYRAYY QGKIQREKYL TILKAVKTLQ
ASFRGARVRK AVRKLQLSAT LIQSYYRRYR QQTYFNKLKK VTKTIQQRYR AVKERNIQLQ
RYTKLRHCII CIQSAFRGMK TRRHFKVMRL AAILIQRRFR TLMVRRKFLS LKKTIIWIQR
KYRAKHDLEQ FLQLRKAVIQ IQSSYRGWMV RKKMQERHRA ATLIQATFRM HRNYVTFQSW
KHAAILIQQQ YRKYRAAKLQ RENFIRQWGS AMVIQAPNKG LKARQVLREK HRAAIIIQST
YRMYRQYCFY KKLQWATKVI QEKYRANKKK QKALQHKACK KEEICIQTFQ DINTRKQIQK
QHEAAVIIQK HFKAFKTRRQ YLYLRATVIS VQRRYRALTA TSTQAVICVQ SSHRGFQEAE
SHSQTWAALT IQRAFRKMIK RRLDTQKCAA LRIQAFLQMA VHRRRFIQQR RAAVTLQQHF
RTWQTRKQFL LHRKAAVVLQ NHYRAFLSTK HQRQSYLQIR SSAIIIQAVM KGFIQKRKFQ
QIKNSTIKIQ GVWRKYKAKK YLCKVKAACK IQAWYRCWSA RKQYLAVLKA VKIIQGCFYT
KLERTRFLKM RTSTIIIQRK WRAMLSARIA REHFLMIKVV IPQILVQSWL VRKKILEERA
KIRILHFTAA TYYHLSALRI QRAFKLHMAM KNAKKQINSV ICIQRWFRAK LQRKKFIEKY
RNTIKTKHEM QEHLNQQNRA ASVIQKAVRR FLLCKRQEKF NNSITKIQAL WRGYSWRKKN
DCTKIKAIRL SLQLVNKEIR EENKLYKRTA LALHDLLTYK HLSAILEALK HLEVVTRLSP
LCCENMAESG AISKVFVLIR SCNRSVPCME VIRHAVQVLL NVAKYEKTTS AVYDVENCID
TLLELLQIYR EKPGDKVADK GGSIFTKTCC LLAVLLKTTN RASDVRSRSK VVDRICSLYK
LTARKHKINT ERIFYKQKQN PSIGIPCIAE KPVRTRIVSR LKPDWILRRD NIEVTNPLQA
IQMVMDTIGI PY
//
