ID G5BNB3_HETGA Unreviewed; 1263 AA.
AC G5BNB3;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Caskin-2 {ECO:0000313|EMBL:EHB10774.1};
GN ORFNames=GW7_04467 {ECO:0000313|EMBL:EHB10774.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB10774.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB10774.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; JH171126; EHB10774.1; -; Genomic_DNA.
DR AlphaFoldDB; G5BNB3; -.
DR STRING; 10181.G5BNB3; -.
DR eggNOG; KOG0507; Eukaryota.
DR eggNOG; KOG4384; Eukaryota.
DR InParanoid; G5BNB3; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR CDD; cd09497; SAM_caskin1_2_repeat1; 1.
DR CDD; cd09498; SAM_caskin1_2_repeat2; 1.
DR CDD; cd12063; SH3_Caskin2; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 2.
DR InterPro; IPR033635; ANKS1/Caskin.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR032232; Caskin1-CID.
DR InterPro; IPR035497; Caskin1/2_SAM_1.
DR InterPro; IPR035498; Caskin1/2_SAM_2.
DR InterPro; IPR035499; Caskin2_SH3.
DR InterPro; IPR032117; Caskin_C.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR24174; ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR24174:SF18; CASKIN-2; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF16907; Caskin-Pro-rich; 1.
DR Pfam; PF16632; Caskin-tail; 1.
DR Pfam; PF16600; Caskin1-CID; 1.
DR Pfam; PF00536; SAM_1; 2.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00454; SAM; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 5.
DR PROSITE; PS50088; ANK_REPEAT; 5.
DR PROSITE; PS50105; SAM_DOMAIN; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT REPEAT 121..153
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 154..186
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 187..219
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 261..293
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 293..325
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 354..420
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 561..624
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 630..694
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 429..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 514..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 748..1156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1176..1240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..451
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 770..804
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 816..847
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 902..926
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 935..964
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1054..1068
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1084..1124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1225..1240
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1263 AA; 133551 MW; 4DDFDED4AD12EE0C CRC64;
MGREQDLILA VKNGDVIGVQ KLVAKVKATK TRPPVPALAA TGHLPVCTCC GEAVPQPLCL
VPAQLSQEPV GAEVAEDPLR PRGMVGSSSL APRRGSMSTT RMLMELLGST KRLNVNYQDA
DGFSALHHAA LGGSLELIAL LLEAQATVDI KDSNGMRPLH YAAWQGRLEP VRLLLRASAA
VNAASLDGQI PLHLAAQYGH YEVSEMLLQH QSNPCLVNKA KKTPLDLACE FGRLKVAQLL
LNSHLCVALL EGEAKDPGDP NYTTPLHLAA KNGHREVIRQ LLRAGIEINR QTKTGTALHE
AALYGKTEVV RLLLEGGVDV NIRNTYNQTA LDIVNQFTTS QASREIKQLL REASGILKVR
ALKDFWNLHD PTALSVRAGD VITVIEQHPD GRWKGHIHES QRGTDRVGYF PPGIVEVVSK
RVGIPMPRLP SVPTPLRPGF SRMPQPPADE PLHPFTYGQL PRVGLSPDSP AGDRNSVGSE
GSVGSIRSAG SGQSSEGTNG HGTGLLIENA QPLPSAGEDQ VLPGLHTPSL ADNLSHRPLA
SYRSGEIVTQ EVRPEQLLEG KDAQAIHNWL SEFQLEGYTA HFLQAGYDVP TISRMTPEDL
TAIGVTKPGH RKKIASEISQ LSIAEWLPSY IPTDLLEWLC ALGLPQYHKQ LVSSGYDSMG
LVADLTWEEL QEIGVNKLGH QKKLMLGVKR LAELRRGLLQ GEALGEGRHR LARGPELMAI
EGLENGEAPA MAGPRLLTFQ GSELSPELQA AMAGGGPEPL PLPPARSPSQ ESIGARSRGS
GHSQEQPAPQ PSGGDPSTPQ ERNLPEGTER PPRLCSPLPG QGPAPYVFMY PQPSPTSPAP
GPPPGAPRAF SYLASSPATP PDPPRPKRRS HSLSRPGPTE GEPEGEAEGP VGSALGSYAT
LTRRPGRSTL ARTSPSPTST RWAPRSQSFA LRARRKGPPP PPPKRLSSVS GPTDPPPPDR
SPGPKEGSTE PRRRTLSEPA GPSEAPSLPI PAGPASDTEE EPGSEGTPPS RGSSGEGLPF
AEEGNLTIKQ RPKPAGPPLR ETPVPPGLDF NLTESDTVKR RPKCKEREPL QTALLAFGVA
SATPSPSAPL TAQAPSEPPS SASSSPAQPE PSSLPTQGAP ALAPSPGTQP SGPPASCPAL
GPETESQAAP AALLKVPRAG TAPKPVSVAC TQLAFSGPKL APRLGPRPVP PPRPENTGAA
GAGRAQQRLE QTSSSLAAAL RAAEKSISAE ERDGDPGTCT KHILDDISTM FDALADQLDA
MLD
//
