ID G5BNG3_HETGA Unreviewed; 1410 AA.
AC G5BNG3;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Putative G-protein coupled receptor 116 {ECO:0000313|EMBL:EHB10904.1};
GN ORFNames=GW7_19181 {ECO:0000313|EMBL:EHB10904.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB10904.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB10904.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
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DR EMBL; JH171133; EHB10904.1; -; Genomic_DNA.
DR STRING; 10181.G5BNG3; -.
DR eggNOG; KOG4193; Eukaryota.
DR InParanoid; G5BNG3; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008078; GPCR_2_Ig-hepta-like_rcpt.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR PANTHER; PTHR45813:SF4; ADHESION G PROTEIN-COUPLED RECEPTOR F5; 1.
DR PANTHER; PTHR45813; EF-HAND DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF01390; SEA; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01695; IGHEPTARCPTR.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00409; IG; 2.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF82671; SEA domain; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS50024; SEA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:EHB10904.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1410
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003474547"
FT TRANSMEM 1078..1105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1117..1138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1158..1181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1193..1215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1235..1263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1284..1304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1310..1333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 182..289
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 438..532
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 533..625
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1076..1334
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 1390..1410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1410 AA; 155817 MW; E0E4429C46D426F3 CRC64;
MQSPGRSALC LVLLVVCFSG VLSSVLDPMD SIELMEFMAH PLVLHEEDHK EDYKEDLESE
ELLSPRCPDA LGIPMVDEYT VDVELSFENV SFLESLRAQL HDLSFPIQVT DTDPVTAILS
IEVTTVCTAT GNEVWCSCES GYEWPQAGCL HNAICREHDG VSSGNPCGCL KELPPQGPFC
QPPTVLTLRM KVRLNVGFQE ELLNTSSALY RSYKTDLERA FQEGYRILPG FRSVAVTEFT
NGSVVVSFEV KTTTLPPGQI QKANELVLQS LNQTYKADEN SFQGVNNETK LSVMPAIIFE
GDTVTLECEN EVLSSNVSWL YGEGLSSLSR LRNGSRHSIY TTVQLTSMSR LTITNFTQED
EAKSLSVQPR EHRYSFPWGS RSICTDHVPP ECSSLSVWTD SQGLRTGSSL ESGPGLYACK
LVMDIFEFGT EKYINVTPIQ ILANETTAVK CDNYPVSLNC CSENEANWTA IEWKQEGNMS
IPGHEDQDLN SGCGRYILQA NTTQCPDTII YMCEFLSGYG ARVGKAIEVT FTPVAELIIT
PEPISVSEGQ SFSITCTSNV RNYDEVYWNT SAGIKIHKRF YATQRHPEGA ESVLTVETST
REWNGTYRCV FRYKNTYSVA TKDVTVHPLP LEPNIMVDPL EASGLCTDSH HFRCCVEEDE
DYKVMFQMGS SFFPAAKEVK GKQVCYKYSS TADSVSQCPK NVDVFCHFTN AANSSVRSSS
MKLTLVPGEN ITCRDPAIGV GEPGKVIQKL CQFSDVSRSP DSTIGGTITY RCVGSQWQVE
RKGCISAPIN GLLQLAEALI KSPSQDQNLP TYLKNLSVST GREELEIQSS PGSLGAVINI
LDLLSTVPSH VDPEMMKDVL ATVNVILGES VLGSWEALQQ DQTSQSSQLL HSVERFSKAL
RPGDSTLVFL RHPNVQMGSM VVKPGKSHSY QQNFHFPASN LWGNVTIEKH QLGNLHPESL
VVTVAFPTLK AILVQDAQKK PFANSLVMTT TISHNITMPF EISMTFKNNH GAGGQIICVF
WNFSLSNNTG GWDSRGCRVN SVDRDRISCT CDHLTSFSIL MSPDSPDRGS LLEILLDIIS
YIGLGFSILS LAACLVVEAV VWKSVTKNRT SYMRHICIVN IAASLLFADA WFIVVAAIQD
HHYPLNDMAC VAATFFIHFF YLSVFFWMLT LGLMLFYRLI FILHDASKST QKAVAFCLGY
GCPLVISVIT VAATQPQEVY TRKNACWLNW DDTKALLAFV IPALLIVVVN MTVTVVVITK
ILRPSIGDKP HNQEKNSLFQ ISKSIGVLTP LLGLTWGFGL ATVFQGTNAV FHIIFTLLNA
FQGLFILLFG CLWDQKVQET LLNKFSLSRQ SSQHSKSTSL GSTTPVFSMS SPISRRFNNL
FGKTGTYNVS TPETTSSSVE NSSSAYSLLH
//
