ID G5BQ22_HETGA Unreviewed; 513 AA.
AC G5BQ22;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE SubName: Full=Cation channel sperm-associated protein 3 {ECO:0000313|EMBL:EHB11383.1};
GN ORFNames=GW7_17815 {ECO:0000313|EMBL:EHB11383.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB11383.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB11383.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
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DR EMBL; JH171310; EHB11383.1; -; Genomic_DNA.
DR AlphaFoldDB; G5BQ22; -.
DR STRING; 10181.G5BQ22; -.
DR eggNOG; KOG2301; Eukaryota.
DR InParanoid; G5BQ22; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 2.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR47131; CATION CHANNEL SPERM-ASSOCIATED PROTEIN 3; 1.
DR PANTHER; PTHR47131:SF1; CATION CHANNEL SPERM-ASSOCIATED PROTEIN 3; 1.
DR Pfam; PF07716; bZIP_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SUPFAM; SSF57959; Leucine zipper domain; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 148..167
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..345
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 357..383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 451..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 62..85
FT /note="BZIP"
FT /evidence="ECO:0000259|Pfam:PF07716"
FT DOMAIN 197..384
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 27..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..77
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 513 AA; 59272 MW; CEBEB5BECCABA60C CRC64;
MSEITQQNST AGVNGIRVIH TQAHASGLQQ VPQLLPAGPG GGGKAVSPSK QSKKSSPMDR
NSDEHRQRRE RNNMAVKKSR LKSKQLHSCG LNIKGVTTYT TQRFMAECRL FPLFKDPLEI
SEMVFVAIYT SEFSMKVYVD PINYWKDGYN LLDVVIIIII FIPYVLHEVK GKHFRYLNIT
DGIQSLRILK LITYSQAIRI SEMVFVAIYT SEFSMKVYVD PINYWKDGYN LLDVVIIIII
FIPYVLHEVK GKHFRYLNIT DGIQSLRILK LITYSQAIRT LITAMGQIVY IVASVLILFF
ILLYIFAILG FYLFGVLERG DMNNWGSLDT IFFTLFSLAT VEGWTDMQTQ LEKHNFIVSR
AFTIIFILLA SFIFLSVFVG VIIMPTEVSL KKFEQDLMLE KHMEEKMQMI LKQQQEEMNR
WMPIQKTETV DKNLSELMEN LKKSRRDTDP MVLSDFATSL LFIDIYLSIL DKQDTTVKQL
QELYCKTMHM LGLMLKDLPQ KKKSESLEKI DEK
//
