ID G5BSJ4_HETGA Unreviewed; 352 AA.
AC G5BSJ4;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Keratocan {ECO:0000256|ARBA:ARBA00041182};
GN Name=KERA {ECO:0000313|EMBL:JAN96015.1};
GN ORFNames=GW7_13648 {ECO:0000313|EMBL:EHB12255.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB12255.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB12255.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
RN [2] {ECO:0000313|EMBL:JAN96015.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Testis {ECO:0000313|EMBL:JAN96015.1};
RA Bens M., Sahm A., Jahn N., Morhart M., Holtze S., Hildebrandt T.B.,
RA Platzer M., Szafranski K.;
RT "FRAMA: From RNA-seq data to annotated mRNA assemblies.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the small leucine-rich proteoglycan (SLRP)
CC family. SLRP class II subfamily. {ECO:0000256|ARBA:ARBA00005818}.
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DR EMBL; JH171641; EHB12255.1; -; Genomic_DNA.
DR EMBL; GEBF01007617; JAN96015.1; -; Transcribed_RNA.
DR RefSeq; XP_004845037.1; XM_004844980.1.
DR AlphaFoldDB; G5BSJ4; -.
DR STRING; 10181.G5BSJ4; -.
DR Ensembl; ENSHGLT00100000375; ENSHGLP00100000345; ENSHGLG00100000294.
DR GeneID; 101725130; -.
DR KEGG; hgl:101725130; -.
DR CTD; 11081; -.
DR eggNOG; KOG0619; Eukaryota.
DR InParanoid; G5BSJ4; -.
DR OMA; MECFCPP; -.
DR OrthoDB; 521898at2759; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR Bgee; ENSHGLG00000010458; Expressed in testis and 2 other cell types or tissues.
DR GO; GO:0061303; P:cornea development in camera-type eye; IEA:Ensembl.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR45712; AGAP008170-PA; 1.
DR PANTHER; PTHR45712:SF13; KERATOCAN; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01462; LRRNT; 1.
DR SMART; SM00364; LRR_BAC; 5.
DR SMART; SM00369; LRR_TYP; 6.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..352
FT /note="Keratocan"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007660785"
FT DOMAIN 41..75
FT /note="LRRNT"
FT /evidence="ECO:0000259|SMART:SM00013"
SQ SEQUENCE 352 AA; 40544 MW; 31DE1B1B1E789A7D CRC64;
MATTISFLIW VLFITDTAWT QSMRQVYDVY EPEDWSMHDF SCPRECFCPP SFPTALYCEN
RGLKEIPAIP SRIWYLYLEN NLIETIPEKS FVNATQLRWI NLNKNKITNY GIEKGALSQL
KKLLFLFLED NELEEVPSPL PRSLEQLQLA RNKVSRIPQG TFSNLENLTL LDLQHNKLLD
SAFQRDTFKG LKNLMQLNMA KNALRNMPPR LPANTMQLFL DNNSIEGIPE NYFNVIPKVA
FLRLNHNKLS DAGLPSRGFD VSSILDLQLS HNQLTKFPQI SARLQHLHLD HNKIRSVNVS
LICPTPPTLH AEQDFFIHGP QLSYLRLDGN EIKPPIPMDL MTCFKLLQAV II
//
