ID G5BSU9_HETGA Unreviewed; 300 AA.
AC G5BSU9;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Estradiol 17-beta-dehydrogenase 11 {ECO:0000256|ARBA:ARBA00039801};
DE EC=1.1.1.62 {ECO:0000256|ARBA:ARBA00024072};
DE AltName: Full=17-beta-hydroxysteroid dehydrogenase 11 {ECO:0000256|ARBA:ARBA00042233};
DE AltName: Full=Dehydrogenase/reductase SDR family member 8 {ECO:0000256|ARBA:ARBA00042911};
GN Name=HSD17B11 {ECO:0000313|EMBL:JAN96723.1};
GN ORFNames=GW7_20323 {ECO:0000313|EMBL:EHB12360.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB12360.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB12360.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
RN [2] {ECO:0000313|EMBL:JAN96723.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Liver {ECO:0000313|EMBL:JAN96723.1};
RA Bens M., Sahm A., Jahn N., Morhart M., Holtze S., Hildebrandt T.B.,
RA Platzer M., Szafranski K.;
RT "FRAMA: From RNA-seq data to annotated mRNA assemblies.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=17beta-estradiol + NAD(+) = estrone + H(+) + NADH;
CC Xref=Rhea:RHEA:24612, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469,
CC ChEBI:CHEBI:17263, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.62;
CC Evidence={ECO:0000256|ARBA:ARBA00035946};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=17beta-estradiol + NADP(+) = estrone + H(+) + NADPH;
CC Xref=Rhea:RHEA:24616, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469,
CC ChEBI:CHEBI:17263, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.62;
CC Evidence={ECO:0000256|ARBA:ARBA00036215};
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. 17-beta-HSD 3 subfamily. {ECO:0000256|ARBA:ARBA00038261}.
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DR EMBL; JH171653; EHB12360.1; -; Genomic_DNA.
DR EMBL; GEBF01006909; JAN96723.1; -; Transcribed_RNA.
DR RefSeq; XP_004870603.1; XM_004870546.2.
DR AlphaFoldDB; G5BSU9; -.
DR STRING; 10181.G5BSU9; -.
DR Ensembl; ENSHGLT00100002901; ENSHGLP00100002846; ENSHGLG00100002197.
DR GeneID; 101722437; -.
DR KEGG; hgl:101722437; -.
DR CTD; 51170; -.
DR eggNOG; KOG1201; Eukaryota.
DR InParanoid; G5BSU9; -.
DR OMA; NTLAHYW; -.
DR OrthoDB; 6845at2759; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR Bgee; ENSHGLG00000009549; Expressed in liver and 10 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005811; C:lipid droplet; IEA:Ensembl.
DR GO; GO:0004303; F:estradiol 17-beta-dehydrogenase [NAD(P)] activity; IEA:Ensembl.
DR GO; GO:0006710; P:androgen catabolic process; IEA:Ensembl.
DR CDD; cd05339; 17beta-HSDXI-like_SDR_c; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR24322:SF489; ESTRADIOL 17-BETA-DEHYDROGENASE 11; 1.
DR PANTHER; PTHR24322; PKSB; 1.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..300
FT /note="Estradiol 17-beta-dehydrogenase 11"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007660897"
SQ SEQUENCE 300 AA; 33146 MW; F1A403E35E9B9CC3 CRC64;
MKFHLSTLLL LPLLLVFSLE SLIKFFIPKK KKSVTGEIVL VTGAGHGIGR LTAFEFAKRK
SKLVLWDINK HGIEETATEC RKLGAQAHTF VVDCSNREGI YSSAKKVKTE IGDVSILVNN
AGVVYTSDLF ATQDPQIEKT FEVNVLAHFW TTKAFLPAMM RNNHGHVVTV ASAAGHTGVP
FLLAYCSSKF AAVGFHRALT EELAALKRTG VKTTCLCPNF INTGFIKNPS TNLGPTLEPE
EVVNKLMNGI LTDQKMIFVP STISFLTVLE RILPERFLAL LKQRINVKFD AVVDYKVKGH
//
