ID   G5BUM3_HETGA            Unreviewed;      1509 AA.
AC   G5BUM3;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   SubName: Full=Nischarin {ECO:0000313|EMBL:EHB12984.1};
GN   ORFNames=GW7_01608 {ECO:0000313|EMBL:EHB12984.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC   Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB12984.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB12984.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA   Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA   Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of the
RT   naked mole rat.";
RL   Nature 479:223-227(2011).
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DR   EMBL; JH171963; EHB12984.1; -; Genomic_DNA.
DR   STRING; 10181.G5BUM3; -.
DR   eggNOG; KOG1259; Eukaryota.
DR   InParanoid; G5BUM3; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005178; F:integrin binding; IEA:InterPro.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   CDD; cd06875; PX_IRAS; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR037904; Nischarin_PX.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   PANTHER; PTHR15454:SF35; NISCHARIN; 1.
DR   PANTHER; PTHR15454; NISCHARIN RELATED; 1.
DR   Pfam; PF00787; PX; 1.
DR   SMART; SM00365; LRR_SD22; 5.
DR   SMART; SM00369; LRR_TYP; 4.
DR   SMART; SM00312; PX; 1.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   PROSITE; PS51450; LRR; 5.
DR   PROSITE; PS50195; PX; 1.
PE   4: Predicted;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          1..116
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
FT   REGION          446..484
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          526..557
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          633..665
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          994..1082
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        641..665
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1010..1025
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1509 AA;  167306 MW;  A2CDFA5980C73F6E CRC64;
     MGLRPSWVWV GLDTRPLGCC LVYIIQVTDG SHEWTVKHRY SDFHDLHEKL IAEKKIDKNL
     LPPKKIIGKN SRSLVEKREK DLEVYLQTLL AVFPGVAPRV LAHFLHFHFY EINGITAALA
     EELYEKGEQL LGAGEVFAIG PLQLYAVTEQ LQQGKPTCAS GDAKTDLGHI LDFTCRLKYL
     KVSCTEGPFG SSNIQEQLLP FDLSIFKSLH QVEISHCDAK HIRGLVASKP TLATLSIRFS
     ATSMKEVLVP EASEFDEWEP EGTALEGPVT AIIPTWQALT TLDLSHNKIS EIDESVKLIP
     KIEFLDLSHN GVLVVDNLQH LYNLVHLDLS YNKLSSLEGV HTKLGNIKTL NLAGNLLESL
     NGLHKLYSLV NLDLSNNRIE QMEEVRSIGS LPCVEHVIIP DYRTKVLAQF GERASEVCLD
     STVTTEKELD TVEVLKAIQK AKDVKSKLNN SEKKVGEDSR LSAAPFVRPS GSPPSTAPTS
     ASLPQPILSN QGVMFVQEEA LASSLSSTDS LTPDDRPIAR ACSDSLESIP AGQASPDDLR
     DVPGAVGGAS PEHTEPEVQV VPGSGQIIFL PFTCIGYTAT NQDFIQRLST LIRQAIERQL
     PAWIEAANQR EEGQGEQGEE DDDEDEEDVV ENRYFEMGPP DTEEEEGGPG EEEEEEEEEE
     AEEERLALEW ALGADEDFLL EHIRILKVLW CFLIHVQGSI RQFAACLVLT DFGIAVFEIP
     HQESRGSSQH ILSSLRFVFC FPHGDLTEFG FLMPELCLVL KVRHSENTLF IISDAANLQE
     FHADLRSCFA PQHMAMLCSP ILYSSHTSLQ EFLRQLLTFY KVAGGCQERS QGCFPVYLVY
     SDKRMVQTAA GDYSGNIEWA SCTLCSAVRR SCCAPSEAVK SAAIPYWLLL TPQHLNVIKA
     DFNPMPNRGT HHCRNRNSFK LSRVPLSTVL LDPTRSCTQP RGAFADGHVL ELLVGYRFVT
     AIFVLPHEKF HFLRIYNQLR ASLQDLKTVV IAKTPTPGTR SQSPLVDGQP AEDRARHDQR
     PQEGPAEAKS RGPAPAPVLA ASAPVPANTL APAPAPEEAS APAPTSAEAQ APPPAPAEAS
     APALVPEEAP IETPTPAAAE ALTQAEAPAQ YPSEQLIQST SEENQIPFHL PVCPSLQHIA
     GLSGKAVIEL FHSSIAEVEN EELRHLLWSS VVFYQTPGLE VTACVLLSTK AVYFVLHDGL
     RRYFSEPLQD FWHQKNTDYN NSPFHISQCF VLKLSDLQSV NVGLFDQHFR LTGSAPAQVV
     TCLTRDSYLT HCFLQHLMLV LSSLERTPSP EPADKDFYSE FGDKTTGKME NYELIHSSRV
     KFTYPSEEEV GDLTYIVAQK TTDPEKAPAP SILLYVQAFQ VDLPPPGSCR GPLRPKTLLL
     TSTEIFLLDE DYIHYPLPEF AKEPPQRDRY RLGDGHRVRD LDRVLMGYQP YPQALTLVFD
     DMQGHDLMGS VTLDHFGEMQ SGSARAGQGR EIQWQIFVPS AESREKLISL LARQWEALCG
     RELPVELTG
//