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Database: UniProt
Entry: G5BUP2_HETGA
LinkDB: G5BUP2_HETGA
Original site: G5BUP2_HETGA 
ID   G5BUP2_HETGA            Unreviewed;      2018 AA.
AC   G5BUP2;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   25-OCT-2017, entry version 28.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
DE   Flags: Fragment;
GN   ORFNames=GW7_01627 {ECO:0000313|EMBL:EHB13003.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Bathyergidae; Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB13003.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB13003.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L.,
RA   Bronson R.T., Buffenstein R., Wang B., Han C., Li Q., Chen L.,
RA   Zhao W., Sunyaev S.R., Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of
RT   the naked mole rat.";
RL   Nature 479:223-227(2011).
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; JH171963; EHB13003.1; -; Genomic_DNA.
DR   InParanoid; G5BUP2; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005452; LVDCC_a1dsu.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF139; PTHR10037:SF139; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   PRINTS; PR01636; LVDCCALPHA1D.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006813};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM      6     26       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     38     57       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    110    133       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    189    210       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    222    244       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    382    400       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    420    443       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    512    531       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    584    611       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    746    764       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    784    804       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    816    842       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    862    892       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    989   1014       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1068   1086       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1098   1118       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1208   1226       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1300   1323       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1457   1491       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      614    645       {ECO:0000256|SAM:Coils}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:EHB13003.1}.
SQ   SEQUENCE   2018 AA;  229439 MW;  F3F65913E0E986AA CRC64;
     EKVEYAFLII FTVETFLKII AYGLLLHPNA YVRNGWNLLD FVIVIVGLFS VILEQLTKET
     EGGNHSSGKS GGFDVKALRA FRVLRPLRLV SGVPSLQVVL NSIIKAMVPL LHIALLVLFV
     IIIYAIIGLE LFIGKMHKTC FFADSDIVAE EDPAPCAFSG NGRQCTANGT ECRSGWVGPN
     GGITNFDNFA FAMLTVFQCI TMEGWTDVLY WVNDAIGWEW PWVYFVSLII LGSFFVLNLV
     LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE NEEEGGEEGK
     RNTSMPTSET ESVNTENVSG EGETKGCCRR LWCWWRRRGT AKTGPSGCRR WGQAISKSKL
     SRRWRRWNRF NRRRCRAAVK SVTFYWLVIV LVFLNTLTIS SEHYNQPGWL TQIQDIANKV
     LLALFTCEML IKMYSLGLQA YFVSLFNRFD CFVVCGGITE TILVELEIMS PLGISVFRCV
     RLLRIFKVTR HWTSLSNLVA SLLNSMKSIA SLLLLLFLFI IIFSLLGMQL FGGKFNFDET
     QTKRSTFDNF PQALLTVFQI LTGEDWNAVM YDGIMAYGGP SSSGMIVCIY FIILFICGNY
     ILLNVFLAIA VDNLADAESL NTAQKEEAEE KERKKIARKE SLENKKNHKP EVNQIANSDN
     KVTVDDYREE DEDKDPYPPC DVPVGEEEEE EEEDEPEVPA GPRPRRISEL NMKEKIAPIP
     EGSAFFILSK TNPIRVGCHK LINHHVFTNL ILVFIMLSSA ALAAEDPIRS HSFRNTILGY
     FDYAFTAIFT VEILLKMTTF GAFLHKGAFC RNYFNLLDML VVGVSLVSFG IQSSAISVVK
     ILRVLRVLRP LRAINRAKGL KHVVQCVFVA IRTIGNIMIV TTLLQFMFAC IGVQLFKGKF
     YRCTDEAKSN PEECRGLFIL YKDGDVDSPV VRERIWQNSD FNFDNVLSAM MALFTVSTFE
     GWPALLYKAI DSNGENVGPV YNYRVEISIF FIIYIIIVAF FMMNIFVGFV IVTFQEQGEK
     EYKNCELDKN QRQCVEYALK ARPLRRYIPK NPYQYKFWYV VNSSPFEYMM FVLIMLNTLC
     LAMQHYEQSK MFNDAMDILN MVFTGVFTVE MVLKVIAFKP KGYFSDAWNT FDSLIVIGSI
     IDVALSEADP TESDNVPVPT ATPGNSEESN RISITFFRLF RVMRLVKLLS RGEGIRTLLW
     TFIKSFQALP YVALLIAMLF FIYAVIGMQM FGKVAMRDNN QINRNNNFQT FPQAVLLLFR
     CATGEAWQEI MLACLPGKLC DPESDYNPGE EYTCGSSFAI VYFISFYMLC AFLIINLFVA
     VIMDNFDYLT RDWSILGPHH LDEFKRIWSE YDPEAKGRIK HLDVVTLLRR IQPPLGFGKL
     CPHRVACKRL VAMNMPLNSD GTVMFNATLF ALVRTALKIK TEGNLEQANE ELRAVIKKIW
     KKTSMKLLDQ VVPPAGDDEV TVGKFYATFL IQDYFRKFKK RKEQGLVGKY PAKNTTIALQ
     AGLRTLHDIG PEIRRAISCD LQDDEPEEKR EEEDVFKRNG ALLGNHVNHV NSDRRDSLQQ
     TNTTHRPLHV QRPSIPPASD TEKPLFPPAG NSVCHSRPNR NSVGKQVPTS TNANLNNANM
     SKAAHGKRPS TGDLEHVSEN GHHSSHKHDR EPPRWSSIKR TRYYEMYIRS DSGDEQFPTI
     CREDPEIHGY FRDPRCLGEQ EYFSSEECYE EDSSPTWSRQ NYSCYNRYLG GTTDFERPRG
     YHPPQGCSED DDSPVCYDSR RSPRRRLLPP TPPPHRRSSF NFECLRRQSS QEEAPPSPTL
     PHRTALPLHL MQQQIMAVAG LDSSRAPKYS PSHSTRSWAT PPATPPYRDW TPCYTPLIQV
     ERSESLDQVN GSLPSLHRSS WYTDEPDISY RTFTPASLTV PSRFRNKNSD KQRSADSLVE
     AVLISEGLGR YARDPKFVSA TKHEIADACD LTIDEMESAA STLLNGSMGP RASGDVGLVS
     HRQDYELQEF GPGYSDEEPD PGRDEEDLAD EMICITTL
//
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