ID   G5BV06_HETGA            Unreviewed;       640 AA.
AC   G5BV06;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   SubName: Full=Cytoplasmic polyadenylation element-binding protein 3 {ECO:0000313|EMBL:EHB13112.1};
GN   ORFNames=GW7_21608 {ECO:0000313|EMBL:EHB13112.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC   Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB13112.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB13112.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA   Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA   Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of the
RT   naked mole rat.";
RL   Nature 479:223-227(2011).
CC   -!- SIMILARITY: Belongs to the RRM CPEB family.
CC       {ECO:0000256|ARBA:ARBA00010347}.
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DR   EMBL; JH172073; EHB13112.1; -; Genomic_DNA.
DR   AlphaFoldDB; G5BV06; -.
DR   STRING; 10181.G5BV06; -.
DR   InParanoid; G5BV06; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0003730; F:mRNA 3'-UTR binding; IEA:InterPro.
DR   GO; GO:0045182; F:translation regulator activity; IEA:InterPro.
DR   CDD; cd19757; Bbox1; 1.
DR   CDD; cd12724; RRM1_CPEB2_like; 1.
DR   CDD; cd12726; RRM2_CPEB2_like; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   Gene3D; 4.10.640.40; Cytoplasmic polyadenylation element-binding protein, ZZ domain; 1.
DR   InterPro; IPR032296; CEBP_ZZ.
DR   InterPro; IPR038446; CEBP_ZZ_sf.
DR   InterPro; IPR034819; CPEB.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   PANTHER; PTHR12566; CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB; 1.
DR   PANTHER; PTHR12566:SF7; CYTOPLASMIC POLYADENYLATION ELEMENT-BINDING PROTEIN 3; 1.
DR   Pfam; PF16366; CEBP_ZZ; 1.
DR   Pfam; PF16367; RRM_7; 1.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR   PROSITE; PS50102; RRM; 2.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW   ProRule:PRU00176}.
FT   DOMAIN          383..470
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   DOMAIN          491..569
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   REGION          1..121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..29
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        30..50
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        90..106
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        107..121
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   640 AA;  70425 MW;  C9DEF259F78AD88B CRC64;
     MQDDLLMDKS KTQPQQQRQQ QQQEQQQQPQ PQPQPEPSTV EAPSTPLSPE TPKPEDSSSV
     PALSSAAAPP APNGPDKMQM ESPLLPGLSF HQPPQQPPPP QEPTAPGASL SPSFGSTWST
     GTTNAVEDSF FQGITPVNGT MLFQNFPHHV NPVFGGTFSP QIGLAQTQHH QPAAAAAAAS
     SASSSWNTHQ SVNAAWSAPS NPWGGLQAGR DPRRAVCVGV GVGVPSPLNP ISPLKKPFSS
     NVIAPPKFPR AAPLTSKSWM EDNAFRTDNG NNLLPFQDRS RPYDTFNLHS LENSLMDMIR
     TDHEPLKGKH YPPSGPPMSF ADIMWRNHFA GRMGINFHHP GTDNIMALNN AFLDDSHGDQ
     ALSSGLSSPT RCQNGERVER YSRKVFVGGL PPDIDEDEIT ASFRRFGPLV VDWPHKAESK
     SYFPPKGYAF LLFQEESSVQ ALIDACLEED GKLYLCVSSP TIKDKPVQIR PWNLSDSDFV
     MDGSQPLDPR KTIFVGGVPR PLRAVELAMI MDRLYGGVCY AGIDTDPELK YPKGAGRVAF
     SNQQSYIAAI SARFVQLQHN DIDKRVEVKP YVLDDQMCDE CQGTRCGGKF APFFCANVTC
     LQYYCEYCWA SIHSRAGREF HKPLVKEGGD RPRHVPFRWS
//