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Database: UniProt
Entry: G5BV55_HETGA
LinkDB: G5BV55_HETGA
Original site: G5BV55_HETGA 
ID   G5BV55_HETGA            Unreviewed;      1074 AA.
AC   G5BV55;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   24-JAN-2024, entry version 68.
DE   RecName: Full=Guanylate cyclase {ECO:0000256|RuleBase:RU003431};
DE            EC=4.6.1.2 {ECO:0000256|RuleBase:RU003431};
GN   ORFNames=GW7_19639 {ECO:0000313|EMBL:EHB13169.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC   Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB13169.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB13169.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA   Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA   Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of the
RT   naked mole rat.";
RL   Nature 479:223-227(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00036920};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13666;
CC         Evidence={ECO:0000256|ARBA:ARBA00036920};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC       Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC       Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004115}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC       family. {ECO:0000256|RuleBase:RU000405}.
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DR   EMBL; JH172079; EHB13169.1; -; Genomic_DNA.
DR   AlphaFoldDB; G5BV55; -.
DR   STRING; 10181.G5BV55; -.
DR   eggNOG; KOG1023; Eukaryota.
DR   InParanoid; G5BV55; -.
DR   OMA; VNFWKAN; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.40.50.2300; -; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR018297; A/G_cyclase_CS.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR   PANTHER; PTHR11920:SF347; HEAT-STABLE ENTEROTOXIN RECEPTOR; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   3: Inferred from homology;
KW   cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW   ECO:0000256|RuleBase:RU003431};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Receptor {ECO:0000313|EMBL:EHB13169.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..1074
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003474762"
FT   TRANSMEM        432..455
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          490..750
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          825..955
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   1074 AA;  123081 MW;  A99984F5C5F15300 CRC64;
     MKSPLLGLAL WALLLQLFQP LLAYWASQMS QKCHSGSYEI SVLMMNNSAF GEALDDLKAA
     VNLGLEIVRE HLQKAGVNVT VNATFIYSEG LIYKSGDCRS STCEGLDLLR AITREKQMGC
     ALMGPSCTYA TYQMYLDTEL NFPMISAGSF GLSCDYKETL TRMMSPARKL LYFLVDFWRV
     NNLPFKTFSW NTSYVFKNGT ESEYCFWYIN ALEAGVSYFS QVLSFKDTVR GTDELQNILK
     SRNRRSNVIV MCGTPQTLES LDLTGAEDIV IILVDLFNNY YFEDNVIAPD YMKNVLVLTL
     PPGNSTINSS LSKRFSQGRT DFALAYLDGT LLFGHVLKTF LENGEIITTS KFAHAFRNLT
     FEGSTGPVTL DGCGDIDNVM VLLYTSVDTK KYKVLLTYDT HINQTTSMDT SPTFIWKNHK
     LPNDIPGRGP QILMIAVFAL AGVLVLLLLI ALLVLRKYKK DNELRQKKWS HIPPENIFPL
     ETNETNHVSL KIDDDKRRDT IQRLRQCKYD QKRVILKDLK HCDGNFTEKQ KIELNKLLQS
     DYYNLTKFYG TVKLDTRIFG VVEYCERGSL REVLNDTISY PDGTFMDWEF KISVLYDIAK
     GMSYLHSSKI EVHGRLKSTN CVVDSRMVVK ITDFGCNSIL PPKKDLWTAP EHLRQAKSSQ
     KGDVYSFGII AQEIVLRRET FYTLSCRDQK EKIFRVENYD ELKPFRPDLF LETAEEKELE
     VYLLVKNCWE EDPEKRPDFK KIENTLAKIF GLFHDQKNES YMDTLIRRLQ LYSRNLEHLV
     EERTQLYKAE RDRADRLNFM LLPRLVVQSL KEKGIVEPEL YEEVTIYFSD IVGFTTICKY
     STPMEVVDML NDLYKSFDQI VDRHDVYKVE TIGDAYVVAS GLPMRNGNRH AIDISKMALD
     ILSFIGTFEL EHLPGLPVWI RIGVHSGPCA AGVVGIKMPR YCLFGDTVNT ASRMESTGLP
     LRIHMSSSTI AILKRTQCQF LYEVRGETYL KGRGTETTYW LTGMKDQEYN LPTPPTVENQ
     QRLQAEFSDM ITSSLQKRQA AGIKRRKPTQ IASYKKGSLE YLQLNTTDQD NTYF
//
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