ID G5BWM1_HETGA Unreviewed; 225 AA.
AC G5BWM1;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=Pentraxin family member {ECO:0000256|RuleBase:RU362112};
GN ORFNames=GW7_00542 {ECO:0000313|EMBL:EHB13682.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB13682.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB13682.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- FUNCTION: Displays several functions associated with host defense: it
CC promotes agglutination, bacterial capsular swelling, phagocytosis and
CC complement fixation through its calcium-dependent binding to
CC phosphorylcholine. Can interact with DNA and histones and may scavenge
CC nuclear material released from damaged circulating cells.
CC {ECO:0000256|ARBA:ARBA00037561}.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|RuleBase:RU362112};
CC Note=Binds 2 calcium ions per subunit. {ECO:0000256|RuleBase:RU362112};
CC -!- SUBUNIT: Homopentamer. Pentaxin (or pentraxin) have a discoid
CC arrangement of 5 non-covalently bound subunits.
CC {ECO:0000256|RuleBase:RU362112}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU362112}.
CC -!- SIMILARITY: Belongs to the pentraxin family.
CC {ECO:0000256|ARBA:ARBA00038102, ECO:0000256|RuleBase:RU362112}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01172}.
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DR EMBL; JH172217; EHB13682.1; -; Genomic_DNA.
DR AlphaFoldDB; G5BWM1; -.
DR STRING; 10181.G5BWM1; -.
DR Ensembl; ENSHGLT00000021200; ENSHGLP00000020997; ENSHGLG00000015003.
DR Ensembl; ENSHGLT00100008797; ENSHGLP00100008695; ENSHGLG00100006473.
DR eggNOG; ENOG502S201; Eukaryota.
DR InParanoid; G5BWM1; -.
DR OMA; MEKLLWC; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR GO; GO:0001849; F:complement component C1q complex binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0030169; F:low-density lipoprotein particle binding; IEA:Ensembl.
DR GO; GO:0050750; F:low-density lipoprotein particle receptor binding; IEA:Ensembl.
DR GO; GO:0010888; P:negative regulation of lipid storage; IEA:Ensembl.
DR GO; GO:0010745; P:negative regulation of macrophage derived foam cell differentiation; IEA:Ensembl.
DR GO; GO:0032945; P:negative regulation of mononuclear cell proliferation; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0032930; P:positive regulation of superoxide anion generation; IEA:Ensembl.
DR GO; GO:0032677; P:regulation of interleukin-8 production; IEA:Ensembl.
DR GO; GO:0042310; P:vasoconstriction; IEA:Ensembl.
DR CDD; cd00152; PTX; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001759; Pentraxin-related.
DR PANTHER; PTHR45869:SF7; C-REACTIVE PROTEIN; 1.
DR PANTHER; PTHR45869; C-REACTIVE PROTEIN-RELATED; 1.
DR Pfam; PF00354; Pentaxin; 1.
DR PRINTS; PR00895; PENTAXIN.
DR SMART; SM00159; PTX; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS51828; PTX_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|RuleBase:RU362112};
KW Metal-binding {ECO:0000256|RuleBase:RU362112};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Signal {ECO:0000256|RuleBase:RU362112}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|RuleBase:RU362112"
FT CHAIN 20..225
FT /note="Pentraxin family member"
FT /evidence="ECO:0000256|RuleBase:RU362112"
FT /id="PRO_5005132374"
SQ SEQUENCE 225 AA; 25453 MW; 8E48DAB5AB97B9EF CRC64;
MEKLLWCFLI LISLSDVFGQ KDMSKKTFVF PKESDNAYVS LKAQLKKPLN AFTVCLRFYT
DLFTTRGYSI FSYATKKHDN EILVFWSKDR GYLLGVGGLE VPFKALEIPM APVHICANWE
SISGIIELWV DGKPQVRKSL QKGYSVGTEA IIILGQDQDS FGGRFDANQS LVGDIGDVNM
WDFVLSPEEI STVYASGTFS PNVLDWRALR FETHGEVFIK PQLWA
//