ID G5BXQ6_HETGA Unreviewed; 1343 AA.
AC G5BXQ6;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Neurofascin {ECO:0000313|EMBL:EHB14067.1};
GN ORFNames=GW7_15814 {ECO:0000313|EMBL:EHB14067.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB14067.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB14067.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC L1/neurofascin/NgCAM family. {ECO:0000256|ARBA:ARBA00008588}.
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DR EMBL; JH172376; EHB14067.1; -; Genomic_DNA.
DR STRING; 10181.G5BXQ6; -.
DR eggNOG; KOG3513; Eukaryota.
DR InParanoid; G5BXQ6; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0030424; C:axon; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 5.
DR CDD; cd05731; Ig3_L1-CAM_like; 1.
DR CDD; cd05845; IgI_2_L1-CAM_like; 1.
DR CDD; cd05875; IgI_hNeurofascin_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR026966; Neurofascin/L1/NrCAM_C.
DR InterPro; IPR026965; NFASC_Ig-like.
DR PANTHER; PTHR44170:SF12; NEUROFASCIN; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF13882; Bravo_FIGEY; 1.
DR Pfam; PF00041; fn3; 5.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13927; Ig_3; 3.
DR SMART; SM00060; FN3; 5.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 6.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 5.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1343
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003474850"
FT TRANSMEM 1213..1234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 42..138
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 144..231
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 245..333
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 338..425
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 431..518
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 522..609
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 631..726
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 728..824
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 829..931
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 935..1031
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1110..1202
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 714..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 916..936
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1013..1057
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1088..1111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1244..1343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 714..730
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1244..1267
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1268..1291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1314..1328
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1329..1343
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1343 AA; 149560 MW; CAF8DE3955741291 CRC64;
MARQQLPPWA QAAFLLLFLL SLGGAIEIPM DPSIQNELTQ PPTITKQSVK DHIVDPRDNI
LIECEAKGNP APSFHWTRNS RFFNIAKDPR VSMRRRSGTL VIDFRSGGRP EEYEGEYQCF
ARNKFGTALS NRIRLQVSKS PLWPKENLDP VVVQEGAPLT LQCNPPPGLP SPVIFWMSSS
MEPITQDKRV SQGHNGDLYF SNVMLQDMQT DYSCNARFHF THTIQQKNPF TLKVLTTRGV
AERTPSFMYP QGTSSSQMVL RGMDLLLECI ASGVPTPGIA WYKKGGDLPS DKAKFENFNK
ALRITNVSEE DSGEYFCLAS NKMGSIRHTI SVRVKAAPYW LDEPKNLILA PGEDGRLVCR
ANGNPKPTVQ WMVNGEPLQS APPNPNREVA GDTIIFRDTQ VSSRAVYQCN TSNEHGYLLA
NAFVSVLDVP PRMLSARNQL IRVILYNRTR LDCPFFGSPI PTLRWFKNGQ GSNLDGGNYH
VYENGSLEIK MIRKEDQGIY TCVATNILGK AENQVRLEVK DPTRIFRMPE DQVAKRGTTV
QLECRVKHDP SLRLTVTWLK DDEPLYIGNR MKKEDDSLTI FGVAERDQGS YTCVASTELD
QDLAKAHLTV LDDQATPTNR LAALPKGRPD RPRDLELTDL AERSVRLTWI PGEDNNSPIT
EYVVQFEEDQ FQPGVWHDHS KFPGSVNSAV LQLSPYVNYQ FRVIAINEVG SSHPSLPSER
YRTSGAPPES NPSDVKGEGT RKNNMEITWT PMNATSAFGP NLRYIVKWRR REARETWNNV
TVWGSRYVVG QTPVYVPYEI RVQAENDFGK GPEPNTVIGY SGEDYPRAAP TDVKVRVMNS
TAIGLQWNRV YSDTVQGQLR EYRAYYWRES SLLKSLWVSQ KRQQASFPSD RTRGVVGHLF
PYSNYRLEMV VVNGRGDGPR SETKEFTTPE GVPSAPRRFR VRQPTLETVT LEWDHPEHPN
GILTGYTLKY VPFNGTKLGK QIVENFSPNQ TKFLVQRSDP VSRYRFTLSA RTQVGSGEAV
TEESPAPPNE ATPTAAPPTL PPTTEGEGAG GAVSSTDAAA XAAATEATAV PIIPTVATAT
AAAATTATTA ASATESPPRS TTRRKAQESA PDEPFIWNVT VFPNSKWANI TWKHNFGPGT
DFVVEYIDSN NTKKTVPVKA QAQPIQLTDL YPGMTYTLRI YPRDNEGISS TVITFMTSTA
YTNNQADIAT QGWFIGLMCA IALLVLILLI VCFIKRSRGG KYPVREKKDV PLGPEDPKEE
NGSFDYSDED NKPLQGSQTS LDGTIKQQES DDSLVDYGEG GEGQFNEDGS FIGQYTVKKD
KEETEGNESS EATSPVNAIY SLA
//
