GenomeNet

Database: UniProt
Entry: G5BYV2_HETGA
LinkDB: G5BYV2_HETGA
Original site: G5BYV2_HETGA 
ID   G5BYV2_HETGA            Unreviewed;      1800 AA.
AC   G5BYV2;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   25-OCT-2017, entry version 28.
DE   RecName: Full=Voltage-dependent P/Q-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   ORFNames=GW7_16072 {ECO:0000313|EMBL:EHB14463.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Bathyergidae; Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB14463.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB14463.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L.,
RA   Bronson R.T., Buffenstein R., Wang B., Han C., Li Q., Chen L.,
RA   Zhao W., Sunyaev S.R., Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of
RT   the naked mole rat.";
RL   Nature 479:223-227(2011).
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1A
CC       gives rise to P and/or Q-type calcium currents. P/Q-type calcium
CC       channels belong to the 'high-voltage activated' (HVA) group and
CC       are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-
CC       IVA (omega-Aga-IVA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; JH172486; EHB14463.1; -; Genomic_DNA.
DR   InParanoid; G5BYV2; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR005448; CACNA1A.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 3.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01632; PQVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006813};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     90    109       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    121    141       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    216    238       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    286    307       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    755    774       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    794    815       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    827    844       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    889    911       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1001   1026       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1082   1100       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1112   1135       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1141   1159       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1171   1188       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1232   1254       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1328   1351       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1488   1522       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      344    380       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1800 AA;  203977 MW;  263CBB27A3D139EB CRC64;
     MYHHCCKKGN VFFSCHVSIV GALRRATIKK SKTDLLNPEE AEDQLADIAS VGSPFARASI
     KSAKLENSTF FHKKERRMRF YIRRMVKTQA FYWTVLSLVA LNTLCVAIVH YNQPDWLSDF
     LYYAEFIFLG LFMSEMFIKM YGLGTRPYFH SSFNCFDCGV IIGSIFEVIW AVIKPGTSFG
     ISVLRALRLL RIFKVTKYWA SLRNLVVSLL NSMKSIISLL FLLFLFIVVF ALLGMQLFGG
     QFNFDEGTPP TNFDTFPAAI MTVFQILTGE DWNEVMYDGI KSQGGVQGGM VFSIYFIVLT
     LFGNCILPKG PRDPGEGKRG DTKVPRPRRA VSVSAASLTL VSDLAIAVDN LANAQELTKD
     EQEEEEAANQ KLALQKAKEV AEVSPLSAAN MSIAVKEQQK NQKPAKSVWE QRTSEMRKQN
     LLASREALYG CELDADERWK AAPGDDEERR RHREADGPEG AERRRRHRHA GAPGAYDGDT
     RREDKERRHR RRNAGIRGVP TTPGWTCLSD VHAVPLAGAL HTDPTMSLSG PNSFFPSVHL
     RRENQGSGVP VSGPNLSTTR PIQQDLGRQD PPLAEDIDNM RNNKLATGES AGPHNGLGHP
     GLPQSLAKMG PSGDPGPTPN PPAVATNPQN SASRRMPNNP GNPANPRPPK TPENSLIVTN
     PSSTQPNSAK TARKPDHTSV DMAPACPPPL NHTVVQVNKN ANPDPLPKKE EEKKEEEEED
     DAGEDGPKPM PPYSSMFILS TTNPLRRLCH YILNLRYFEM CILMVIAMSS IALAAEDPVQ
     PNAPRNNVLR YFDYVFTGVF TFEMVIKMID LGLVLHQGAY FRDLWNILDF IVVSGALVAF
     AFTGNSKGKD INTIKSLRVL RVLRPLKTIK RLPKLKAVFD CVVNSLKNVF NILIVYMLFM
     FIFAVVAVQL FKGKFFHCTD ESKEFEKDCR GKYLLYEKNE VKARDREWKK YEFHYDNVLW
     ALLTLFTVST GEGWPQVLKH SVDATFENQG PSPGYRMEMS IFYVVYFVVF PFFFVNIFVA
     LIIITFQEQG DKMMEEYSLE KNERACIDFA ISAKPLTRHM PQNKQSFQYR MWQFVVSPPF
     EYTIMAMIAL NTIVLMMKFY GASAAYENAL RVFNIVFTSL FSLECVLKVM AFGILNYFRD
     AWNIFDFVTV LGSITDILVT EFGNYFRDAW NIFDFVTVLG SITDILVTEF GNNFINLSFL
     RLFRAARLIK LLRQGYTIRI LLWTFVQSFK ALPYVCLLIA MLFFIYAIIG MQVFGNIGID
     GEDEDSDEDE FQITEHNNFR TFFQALMLLF RSATGEAWHN IMLSCLSGKP CDKNSGILTA
     DCGNEFAYFY FVSFIFLCSF LMLNLFVAGI MDNFEYLTRD SSILGPHHLD EYVRVWAEYD
     PAAWGRMPYP DMYQMLRHMS PPLGLGKKCP ARVAYKRLLR MDLPVADDNT VHFNSTLMAL
     IRTALDIKIA KGGADKQQMD AELRKEMMAI WPNLSQKTLD LLVTPHKSTD LTVGKIYAAM
     MIMEYYRQSK AKKLQAMREE QNRTPLMFQR MEPPSPTQEG GPGQNALPST QLDPGGGLMA
     HDSSVKESPS WVTQRAKEMF QKTGTWSPER GPPSDLPNSQ PNPQAVEMRE MSTEGYSDSE
     HYLPMEGQAR AASMPRLPAE NQTISDTSPM KRSASVLGPK ARRLDDYSLE RVPPEDNQRH
     HQRRRDRGHR ASERSLGRYT DIDTGLGTDL SMTTQSGELP SKERDQERGR PKDRKQLQHH
     HHHHHHHPPP DKERYGPERE RPDHSRTRAR DQHWSRSPSE GREHTAHRQD SGCCSITSAI
//
DBGET integrated database retrieval system