ID G5BZ31_HETGA Unreviewed; 312 AA.
AC G5BZ31;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=NK1 transcription factor-related protein 2 {ECO:0000313|EMBL:EHB14542.1};
GN ORFNames=GW7_10056 {ECO:0000313|EMBL:EHB14542.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB14542.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB14542.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
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DR EMBL; JH172515; EHB14542.1; -; Genomic_DNA.
DR RefSeq; XP_004838816.1; XM_004838759.1.
DR AlphaFoldDB; G5BZ31; -.
DR GeneID; 101725966; -.
DR KEGG; hgl:101725966; -.
DR CTD; 390010; -.
DR eggNOG; KOG0488; Eukaryota.
DR InParanoid; G5BZ31; -.
DR OMA; IHHKISF; -.
DR OrthoDB; 679932at2759; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR24340; HOMEOBOX PROTEIN NKX; 1.
DR PANTHER; PTHR24340:SF17; NK1 TRANSCRIPTION FACTOR-RELATED PROTEIN 2; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT DOMAIN 161..221
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 163..222
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 46..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 312 AA; 32345 MW; 6F094B19B3A94C06 CRC64;
MLAWQDGGAK AAPSHHKISF SVLDILDPQK FTRAALPAVR LAPREAKKSL AEVEAGKEVS
PGDPVRLQES PDAAGPGAGP ASPLEGSEAE EDEEDADDAG RAPRRERAAH LQTGRAGSPE
ARVATLAAAE CSADGEGGLS GSPGSPGSPR PRRRRAEPSC AKPRRARTAF TYEQLVALEN
KFRATRYLSV CERLNLALSL SLTETQVKIW FQNRRTKWKK QNPGADGAAQ AEGGAPQPGT
LGAAAGTCGG GTGGSPGPPG PGALPFQTFP SYSAANVLFP AAASFSLTAA AGNPFAPFLG
PSYLTPFYTP HL
//
