ID G5BZP5_HETGA Unreviewed; 633 AA.
AC G5BZP5;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Protection of telomeres protein 1 {ECO:0000256|ARBA:ARBA00015253};
DE Flags: Fragment;
GN ORFNames=GW7_10442 {ECO:0000313|EMBL:EHB14756.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB14756.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB14756.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC {ECO:0000256|ARBA:ARBA00004574}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the telombin family.
CC {ECO:0000256|ARBA:ARBA00008442}.
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DR EMBL; JH172612; EHB14756.1; -; Genomic_DNA.
DR AlphaFoldDB; G5BZP5; -.
DR STRING; 10181.G5BZP5; -.
DR eggNOG; KOG4757; Eukaryota.
DR InParanoid; G5BZP5; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0043047; F:single-stranded telomeric DNA binding; IEA:InterPro.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd04497; hPOT1_OB1_like; 1.
DR CDD; cd04498; hPOT1_OB2; 1.
DR CDD; cd20374; Pot1C; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 2.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR028389; POT1.
DR InterPro; IPR048953; POT1_C_insert.
DR InterPro; IPR032042; POT1PC.
DR InterPro; IPR011564; Telomer_end-bd_POT1/Cdc13.
DR PANTHER; PTHR14513; PROTECTION OF TELOMERES 1; 1.
DR PANTHER; PTHR14513:SF0; PROTECTION OF TELOMERES PROTEIN 1; 1.
DR Pfam; PF02765; POT1; 1.
DR Pfam; PF21375; POT1_C_insert; 1.
DR Pfam; PF16686; POT1PC; 1.
DR SMART; SM00976; Telo_bind; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 2.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022895};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Telomere {ECO:0000256|ARBA:ARBA00022895}.
FT DOMAIN 7..137
FT /note="Telomeric single stranded DNA binding POT1/Cdc13"
FT /evidence="ECO:0000259|SMART:SM00976"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHB14756.1"
SQ SEQUENCE 633 AA; 70933 MW; 28DF312F0BF913DA CRC64;
PVTNYIYTPL NQLKGGTIVN VYGVVKFFKP PYLSKGTDYC SVVTIVDQTN VKLTCLLFSG
NYEALPRIYK IGDIVRFHRL KIQVYKNEPQ GITSSGFASL TFEGTLGAPV IPRTSSKCFH
FTAADHKMVE ALRIWSSTHI SPSSTLVQLC DVQPMQYFDL TCQLLGKAQV DGASFLLKVW
DGTRTPFPSW RVSIEDHVLE GDLNHIRRLQ NLTIDILVYD NHVQVAKSLK IGSFLRIYSL
HTKLQSVTSE SQAPLSLEFH LHGGTSYGRG VTVLPESNSD VDQLKKALET ADLTAAQHSD
GLYQSDHEDS YLTLSSSGSV SLYEVERCQQ LSATILTDHQ YLEKTPLCAI LKQKAPQQYR
IRAKLRSYKP KRLFQSVKLY CPKCHSLQEV PHEDNLDAVL RDGATKTPDT KLQNTPLYDS
QIWTTEDQGG RKVVIHFVKY NGILPLSNEC LILIEGGTVG EICKLSSEFH SIIPVKSGPK
DLELLDLSVP FLVQGRLYHY GCKQCSSLKP VQNLNSLVGE TSWIPSSVAE VLGIVPLQHV
FVMTFTLDDG TGVLEAYLMD SDKFFQIPAS EVLRDDDLQR NMDLIMDMFC PPGTKIDAYP
WMECVIKSYN VTNGMEQQIC YQIFDTTVAD DVI
//
