ID G5C0C4_HETGA Unreviewed; 195 AA.
AC G5C0C4;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=3'-5' exoribonuclease CSL4-like protein {ECO:0000313|EMBL:EHB14977.1};
DE SubName: Full=Exosome complex component CSL4 {ECO:0000313|EMBL:JAN98888.1};
GN Name=EXOSC1 {ECO:0000313|EMBL:JAN98888.1};
GN ORFNames=GW7_09236 {ECO:0000313|EMBL:EHB14977.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB14977.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB14977.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
RN [2] {ECO:0000313|EMBL:JAN98888.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Skin {ECO:0000313|EMBL:JAN98888.1};
RA Bens M., Sahm A., Jahn N., Morhart M., Holtze S., Hildebrandt T.B.,
RA Platzer M., Szafranski K.;
RT "FRAMA: From RNA-seq data to annotated mRNA assemblies.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
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DR EMBL; JH172633; EHB14977.1; -; Genomic_DNA.
DR EMBL; GEBF01004744; JAN98888.1; -; Transcribed_RNA.
DR RefSeq; XP_004838645.1; XM_004838588.1.
DR AlphaFoldDB; G5C0C4; -.
DR STRING; 10181.G5C0C4; -.
DR Ensembl; ENSHGLT00100069648; ENSHGLP00100048869; ENSHGLG00100040055.
DR GeneID; 101725849; -.
DR KEGG; hgl:101725849; -.
DR CTD; 51013; -.
DR eggNOG; KOG3409; Eukaryota.
DR InParanoid; G5C0C4; -.
DR OMA; YYCSTAR; -.
DR OrthoDB; 297439at2759; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR Bgee; ENSHGLG00000016927; Expressed in ovary and 10 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0006401; P:RNA catabolic process; IEA:Ensembl.
DR GO; GO:0006396; P:RNA processing; IEA:Ensembl.
DR CDD; cd05791; S1_CSL4; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR039771; Csl4.
DR InterPro; IPR019495; EXOSC1_C.
DR InterPro; IPR025721; Exosome_cplx_N_dom.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR003029; S1_domain.
DR PANTHER; PTHR12686; 3'-5' EXORIBONUCLEASE CSL4-RELATED; 1.
DR PANTHER; PTHR12686:SF8; EXOSOME COMPLEX COMPONENT CSL4; 1.
DR Pfam; PF14382; ECR1_N; 1.
DR Pfam; PF10447; EXOSC1; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF110324; Ribosomal L27 protein-like; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT DOMAIN 66..147
FT /note="S1 motif"
FT /evidence="ECO:0000259|SMART:SM00316"
SQ SEQUENCE 195 AA; 21422 MW; 731BFDCEEF1E7C07 CRC64;
MAPPVRYCVP GERLCNLEEG SPGSGTYTRH GYIFSSLAGC LTKSSENGAL PVVSVMRETE
SQLLPDVGAI VTCKVSSINS RFAKVYILYV GSTPLKNSFR GTIRKEDVRA TEKDKVEIYK
SFRPGDIVLA KVISLGDAQS NYLLTTAENE LGVVVAHSES GVQMVPISWC EMQCPKTHTK
EFRKVARVQP EFLQT
//
