ID   G5C2G4_HETGA            Unreviewed;       626 AA.
AC   G5C2G4;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   SubName: Full=Disulfide-isomerase-like protein of the testis {ECO:0000313|EMBL:EHB15725.1};
GN   ORFNames=GW7_15577 {ECO:0000313|EMBL:EHB15725.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC   Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB15725.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB15725.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA   Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA   Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of the
RT   naked mole rat.";
RL   Nature 479:223-227(2011).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen
CC       {ECO:0000256|ARBA:ARBA00004319}.
CC   -!- SIMILARITY: Belongs to the protein disulfide isomerase family.
CC       {ECO:0000256|ARBA:ARBA00006347}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JH173077; EHB15725.1; -; Genomic_DNA.
DR   AlphaFoldDB; G5C2G4; -.
DR   STRING; 10181.G5C2G4; -.
DR   eggNOG; KOG0190; Eukaryota.
DR   InParanoid; G5C2G4; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   CDD; cd02961; PDI_a_family; 1.
DR   CDD; cd02995; PDI_a_PDI_a'_C; 1.
DR   CDD; cd02982; PDI_b'_family; 1.
DR   CDD; cd02981; PDI_b_family; 1.
DR   Gene3D; 3.40.30.10; Glutaredoxin; 4.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   PANTHER; PTHR18929; PROTEIN DISULFIDE ISOMERASE; 1.
DR   PANTHER; PTHR18929:SF58; PROTEIN DISULFIDE-ISOMERASE-LIKE PROTEIN OF THE TESTIS; 1.
DR   Pfam; PF00085; Thioredoxin; 1.
DR   Pfam; PF13848; Thioredoxin_6; 1.
DR   SUPFAM; SSF52833; Thioredoxin-like; 4.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Isomerase {ECO:0000313|EMBL:EHB15725.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..626
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003475031"
FT   DOMAIN          370..496
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000259|PROSITE:PS51352"
FT   REGION          515..548
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          563..626
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        515..538
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        589..626
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   626 AA;  72779 MW;  C32FDF0C4804FADB CRC64;
     MELLWTAMLM VASWVPAAHS SREQDATVPS INLSQPLHVV EENNLLVLTP AGLAQMLNET
     RFLMVLFRAY NSPSKQSRNL AEELGKAVRM LGKGKNGIAF GKVDITVEKE LKQEFYITKA
     PDLKLFFEGD RSKPISCKGV VESAALVVWL RRQISQKAFL FNDSQQAIDF VNSRPVVIIG
     FFQDLGEEVA EAFYDVIKDF PELTFGVMQI KNTFGCFHVI LDSVLVFKKG RVVNRQELIN
     DNTYKQDLYG VIRNHLTDFV VEYNSKNKDL IYEMNVLNHM LLFVSRRAES YRAITRQYKL
     ASKEFQNKIL FVLVDVDEHR NRHVLEYFHI TEFNVPSVQI LNLSSDAQYK MPSDEITYEN
     LKDFGSSFLS RRAKKHQSSE EIPNYWDQGL VKQLVGKNFN VVVFDKERDV FVMFYAPWSE
     KCRVLFPLLE ELGRKYQNHT TVTIAKIDIT ANDIQLKNPD RYPFFRLFPT DSEQAVPYTG
     EHTLQGISDF LESQVKIRTE DEDELLSIEQ NEMIEEGVLA EEEEEEEEEE EEEEEGRTYM
     EPELPGQQFP EQLENMCKVE APVEELPEQE DETKLEMPVE ELPEQEDVTE VEVLVRQKKR
     SEKEEEAAKQ KRPPRREKKF KVKEEL
//