ID G5C371_HETGA Unreviewed; 535 AA.
AC G5C371;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Splicing factor, arginine/serine-rich 12 {ECO:0000313|EMBL:EHB15982.1};
GN ORFNames=GW7_06920 {ECO:0000313|EMBL:EHB15982.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB15982.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB15982.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
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DR EMBL; JH173147; EHB15982.1; -; Genomic_DNA.
DR AlphaFoldDB; G5C371; -.
DR STRING; 10181.G5C371; -.
DR eggNOG; KOG4676; Eukaryota.
DR InParanoid; G5C371; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd12519; RRM1_SREK1; 1.
DR CDD; cd12260; RRM2_SREK1; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR034192; SREK1_RRM2.
DR PANTHER; PTHR32343; SERINE/ARGININE-RICH SPLICING FACTOR; 1.
DR PANTHER; PTHR32343:SF71; SPLICING REGULATORY GLUTAMINE_LYSINE-RICH PROTEIN 1; 1.
DR Pfam; PF00076; RRM_1; 2.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS50102; RRM; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT DOMAIN 19..98
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 182..258
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 289..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..333
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..424
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..512
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..535
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 535 AA; 60480 MW; 1D0BE90DC4F06DB1 CRC64;
MNSGGGFGLG LGFGLTPTAV IQVTNLSSAV TSEQMRTLFS FLGEIEELRL YPPDNAPLAF
SSKVCYVKFR DPSSVGVAQH LTNTVFIDRA LIVVPCAEGK IPEESKALSL LAPAPTMTSL
MPGAGLLPIP TPNPLTTLGV SLSSLGAIPA AALDPNIATL GEIPQPPLMG NVDPSKIDEI
RRTVYVGNLN SQTTTADQLL EFFKQVGEVK FVRMAGDETQ PTRFAFVEFA DQNSVPRALA
FNGVMFGDRP LKINHSNNAI VKPPEMTPQA AAKELEEVMK RVREAQSFIS AAIEPESGKS
SERKGGRSRS HTRSKSRSSS KSHSRRKRSQ SKHREKEREK EREREKEREK EKERGKNKDR
DKEREKDREK DKEKDRERER EKEHEKERDK EKEKEQDKEK EREKDRSKEI DEKRKKDKKS
RTPPRSYNAS RRSRSSSSRN KKDKKREKER DHVSEKRERE RSTSTRKSSN DRDGKEKLEK
NSTSVKEKEH NKEPDSSVGK EVDDKDTPRT EENKVQQNGN CQPNEENLST KTEAV
//
