ID G5C3T2_HETGA Unreviewed; 447 AA.
AC G5C3T2;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Protein kinase C iota type {ECO:0000313|EMBL:EHB16193.1};
GN ORFNames=GW7_07464 {ECO:0000313|EMBL:EHB16193.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB16193.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB16193.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
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DR EMBL; JH173188; EHB16193.1; -; Genomic_DNA.
DR AlphaFoldDB; G5C3T2; -.
DR STRING; 10181.G5C3T2; -.
DR InParanoid; G5C3T2; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.60.20; -; 2.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR PANTHER; PTHR24356:SF214; PROTEIN KINASE C IOTA TYPE; 1.
DR PANTHER; PTHR24356; SERINE/THREONINE-PROTEIN KINASE; 1.
DR Pfam; PF00130; C1_1; 2.
DR SMART; SM00109; C1; 2.
DR SUPFAM; SSF57889; Cysteine-rich domain; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR PROSITE; PS50081; ZF_DAG_PE_2; 2.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:EHB16193.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Transferase {ECO:0000313|EMBL:EHB16193.1};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 17..67
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 228..278
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT REGION 103..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 447 AA; 49408 MW; 005A98C26A7AC532 CRC64;
MHHRAAGCWE KLYYPNGHTF QAKRFSRQAH CAVYTDCVGG LGHQVYKCTN CKPSVHKKCH
KLVTIECGQH SLSSEPMVPV DPSSMTSDPA HTVITHNLST HEALEQDDEE NEAGNTGESG
KASSGLGLED FDLLQVIGRE SYGKVLLVQL KELNPMYAIK AVKKEHFDIH QLELEETIRL
SELKKDSELL IHSLPCIPEH PKVPCPGEEK SMHHRAAGCW EKLYYPNGHT FQAKRFSRQA
HCAVYTDCVG GLGHQVYKCT NCKPSVHKKC HKLVTTECGQ HSLSSEPMVP VDPSSMTSDP
AHTVITHNLS THEALEQDDE ENEAGNTGES GKASSGLGLE DFDLLQVIGR ESYGKVLLVQ
LKELNPMYAI KAVKKEHFDI HQVKHVVMKT SAISISHLHD HLNHACDIQA RGYSLQEHSS
ILATQINGTA LRPATGKHKA GRATADP
//
