ID G5C4H8_HETGA Unreviewed; 248 AA.
AC G5C4H8;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Pulmonary surfactant-associated protein A {ECO:0000313|EMBL:EHB16439.1};
GN ORFNames=GW7_13745 {ECO:0000313|EMBL:EHB16439.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB16439.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB16439.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; JH173383; EHB16439.1; -; Genomic_DNA.
DR RefSeq; XP_004867814.1; XM_004867757.1.
DR RefSeq; XP_004867815.1; XM_004867758.1.
DR AlphaFoldDB; G5C4H8; -.
DR STRING; 10181.G5C4H8; -.
DR Ensembl; ENSHGLT00100001287; ENSHGLP00100001251; ENSHGLG00100000990.
DR GeneID; 101715701; -.
DR KEGG; hgl:101715701; -.
DR eggNOG; KOG4297; Eukaryota.
DR InParanoid; G5C4H8; -.
DR OMA; NDRSCLQ; -.
DR OrthoDB; 4641030at2759; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR Bgee; ENSHGLG00000010093; Expressed in multicellular organism.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0005615; C:extracellular space; IEA:UniProt.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0007585; P:respiratory gaseous exchange by respiratory system; IEA:UniProtKB-KW.
DR CDD; cd03591; CLECT_collectin_like; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR018378; C-type_lectin_CS.
DR InterPro; IPR033990; Collectin_CTLD.
DR InterPro; IPR016187; CTDL_fold.
DR PANTHER; PTHR22801:SF61; C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER F ISOFORM X1-RELATED; 1.
DR PANTHER; PTHR22801; LITHOSTATHINE; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF57944; Triple coiled coil domain of C-type lectins; 1.
DR PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 4: Predicted;
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lectin {ECO:0000256|ARBA:ARBA00022734};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..248
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003475194"
FT DOMAIN 134..247
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT REGION 31..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 248 AA; 26272 MW; 084500A391A86CF4 CRC64;
MLLCSLAFTL ILMAVSGIMC NRTEYCVGSP GIPGTPGSHG LPGRDGRDGV KGEPGPPGPM
GPPGGMPGFP GCNGMSGIPG VPGERGDKGD PGERGPPGLP ASLDEQIQTI LHDFKHKILQ
STGVLILQGS MMAVGDKVFA TNGQSVDFNA IKETCVRAGG DIAAPRSPEE NAAIASIVKK
HNTYTYLGLM EGHTIGDFRY LDGAPVNYTN WYPGEPRGWG KEKCVEMYSD GTWNDRNCVQ
YRLAICEF
//
