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Database: UniProt
Entry: G5C4K4_HETGA
LinkDB: G5C4K4_HETGA
Original site: G5C4K4_HETGA 
ID   G5C4K4_HETGA            Unreviewed;      2368 AA.
AC   G5C4K4;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   25-OCT-2017, entry version 26.
DE   RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   ORFNames=GW7_21789 {ECO:0000313|EMBL:EHB16498.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Bathyergidae; Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB16498.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB16498.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L.,
RA   Bronson R.T., Buffenstein R., Wang B., Han C., Li Q., Chen L.,
RA   Zhao W., Sunyaev S.R., Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of
RT   the naked mole rat.";
RL   Nature 479:223-227(2011).
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. This channel gives
CC       rise to T-type calcium currents. T-type calcium channels belong to
CC       the "low-voltage activated (LVA)" group and are strongly blocked
CC       by nickel and mibefradil. A particularity of this type of channels
CC       is an opening at quite negative potentials, and a voltage-
CC       dependent inactivation. T-type channels serve pacemaking functions
CC       in both central neurons and cardiac nodal cells and support
CC       calcium signaling in secretory cells and vascular smooth muscle.
CC       They may also be involved in the modulation of firing patterns of
CC       neurons which is important for information processing as well as
CC       in cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; JH173384; EHB16498.1; -; Genomic_DNA.
DR   InParanoid; G5C4K4; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0008332; F:low voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0070509; P:calcium ion import; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR030154; VDCC_T_a1G.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF137; PTHR10037:SF137; 2.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006813};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     36     55       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    127    150       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    255    276       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    282    307       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    810    830       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    842    866       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    898    917       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    974    997       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1308   1326       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1346   1367       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1443   1465       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1545   1568       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1650   1671       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1683   1706       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1784   1803       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1867   1889       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        1    318       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      714   1002       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1306   1578       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1649   1899       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1577   1611       {ECO:0000256|SAM:Coils}.
FT   COILED     1888   1912       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2368 AA;  261454 MW;  4C94B7B19A91F52B CRC64;
     MLVILLNCVT LGMFRPCEDI ACDSQRCRIL QAFDDFIFAF FAVEMVVKMV ALGIFGKKCY
     LGDTWNRLDF FIVIAGMLEY SLDLQNVSFS AVRTVRVLRP LRAINRVPSM RILVTLLLDT
     LPMLGNVLLL CFFVFFIFGI VGVQLWAGLL RNRCFLPENF SLPLSVDLEP YYQTENEDES
     PFICSQPREN GMRSCRSVPT LRGEGSGGPP CGLDYEAYNS SSNTTCVNWN QYYTNCSAGE
     HNPFKGAINF DNIGYAWIAI FQVITLEGWV DIMYFVMDAH SFYNFIYFIL LIIVGSFFMI
     NLCLVVIATQ FSETKQRESQ LMREQRVRFL SNASTLASFS EPGSCYEELL KYLVYILRKA
     ARRLARLSRA VGVRAGLLSS PAPLGGXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
     XXXXXXXXXX XXXXXXSSPA PLGGREPQPS SSCSRAHRRL SVHHLVHHHH HHHHHYHLGN
     GALRAPRASP EIQDKSANGS RRFVLPPPST PTLAGPPPVG AESVHSFYHA DCHLEPVRCQ
     ASPPRSPSEA SGRTVDSGKV YPTVHASPPP EMLKEKALVE VASSSGPSTL ASLNIPPGPY
     SSMQKLLETQ STGTCQSSCK FSGPCSKADS GACGPDSCPY CARTRAGELE PGEHEIPDSD
     SEAVYEFTQD AQHSDLRDPH SRQRQSLGTD AEPSSVLAFW RLICDTFQKI VDSKYFGRGI
     MIAILVNTLS MGIEYHEQPS PQQLHPSSPV AAEPAGVYGH LPANQTLVLQ EEELGLRNKQ
     AFGGPFLDSQ PCPHFPGILR PEELTNALEI SNIVFTSLFA LEMLLKLLVY GPFGYIKNPY
     NIFDGVIVVI SVWEIVGQQG GGLSVLRTFR LMRVLKLVRF LPALQRQLVV LMKTMDNVAT
     FCMLLMLFIF IFSILGMHLF GCKFASERDG DTLPDRKNFD SLLWAIVTVF QILTQEDWNK
     VLYNGMASTS SWAALYFIAL MTFGNYVLFN LLVAILVEGF QAEEISKRED ASGQLSCIQL
     PVDSQGGDAT KSESEPDFFS PSVDGDGDGK KRLALVSLGQ HPELHKSLLP PLIIHTAATP
     MSLPKSSSTG LGEALGSGSC RTSSSGSAEP GAAHEMKSPP STRSSPHSPW SAASSCRRSS
     RNSLSRAPSL KRRSPSGERR SLLSGEGRES QDEDESSEEE RASPAGSDCR PRGSLEREAK
     SSFDLPDTLQ VPGLHLTASG RSSASEHQDC NGKSASGRLA RALRPDDPAL DGDDGDDEGN
     LSKGERIRAW IRARLPACCR ERDSWSAYIF PPQSRFRLLC HRIITHKMFD HVVLVIIFLN
     CITIAMERPK IDPHSAERIF LTLSNYIFTA VFLAEMTVKV VALGWCFGEQ AYLRSSWNVL
     DGLLVLISVI DILVSMVSDS GTKILGMLRV LRLLRTLRPL RVISRAQGLK LVVETLMSSL
     KPIGNIVVIC CAFFIIFGIL GVQLFKGKFF VCQGEDTRNI TNKSDCAEAS YRWVRHKYNF
     DNLGQALMSL FVLASKDGWV DIMYDGLDAV GVDQQPIMNH NPWMLLYFIS FLLIVAFFVL
     NMFVGVVVEN FHKCRQHQEE EEARRREEKR LKRLEKKRRS KEKQMADLML DDVIASGSSA
     SAASEAQCKP YYSDYSRFRL LVHHMCTSHY LDLFITGVIG LNVVTMAMEH YQQPQILDEA
     LKICNYIFTV IFVLESVFKL VAFGFRRFFQ DRWNQLDLAI VLLSIMGITL EEIEVNASLP
     INPTIIRIMR VLRIARVLKL LKMAVGMRAL LDTVMQALPQ VGNLGLLFML LFFIFAALGV
     ELFGDLECDE THPCEGLGRH ATFRNFGMAF LTLFRVSTGD NWNGIMKDTL RDCDQESTCY
     NTVISPIYFV SFVLTAQFVL VNVVIAVLMK HLEESNKEAK EEAELEAELE LEMKTLSPQA
     HSPLGSPFLW PGVQGPDSPD SPKSRAPHEA AHSLEHPTDR QLFDTISLLI QGSLDGELKL
     MDELAGPGGQ PSAFPSAPGP GGSDPQIPLA EMEALSLTSE IVSEPSCSLA LTDDSLPDDP
     HTLLLSALES SVHAHAPHAP LAGWAGLAAR LQMEPHPEEA PSALGPNLLT VRKSGVSRTH
     SLPNDSYMCR NGSTGEGSLG HRSWGLPKAQ SGSILSVHSQ PADTSYNPQL PKDPPHMLPP
     HSAPTWSTIP KLPPPGRSPL AQRPLRRQAA VRTDSLDVQG LGSQEDLLSE VSRPSPPLAR
     SSSFWGRSSV QAQQHFRSLS KVSKHIPPPA PCLGPEPHWS KGPPETRSSL ELDTELSWVS
     GDLLATDGQE EPASPRDLKK CYSVEAQSCR RRPASWLDEX XXXXXXXXXX XXXXXXXXXX
     XXXXASGASL LGGLGAAPRK NSARPVSP
//
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