ID G5C5F6_HETGA Unreviewed; 699 AA.
AC G5C5F6;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Ladybird homeobox corepressor 1 {ECO:0000313|EMBL:EHB16767.1};
DE Flags: Fragment;
GN ORFNames=GW7_10525 {ECO:0000313|EMBL:EHB16767.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB16767.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB16767.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SIMILARITY: Belongs to the SKI family. {ECO:0000256|ARBA:ARBA00009513}.
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DR EMBL; JH173431; EHB16767.1; -; Genomic_DNA.
DR STRING; 10181.G5C5F6; -.
DR eggNOG; ENOG502QQC2; Eukaryota.
DR InParanoid; G5C5F6; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046332; F:SMAD binding; IEA:InterPro.
DR CDD; cd21080; DHD_Skor; 1.
DR Gene3D; 3.10.390.10; SAND domain-like; 1.
DR Gene3D; 3.10.260.20; Ski; 1.
DR InterPro; IPR014890; c-SKI_SMAD4-bd_dom.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR010919; SAND-like_dom_sf.
DR InterPro; IPR003380; SKI/SNO/DAC.
DR InterPro; IPR037000; Ski_DNA-bd_sf.
DR InterPro; IPR023216; Tscrpt_reg_SKI_SnoN.
DR PANTHER; PTHR10005:SF8; SKI FAMILY TRANSCRIPTIONAL COREPRESSOR 1; 1.
DR PANTHER; PTHR10005; SKI ONCOGENE-RELATED; 1.
DR Pfam; PF08782; c-SKI_SMAD_bind; 1.
DR Pfam; PF02437; Ski_Sno; 1.
DR SMART; SM01046; c-SKI_SMAD_bind; 1.
DR SUPFAM; SSF46955; Putative DNA-binding domain; 1.
DR SUPFAM; SSF63763; SAND domain-like; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000313|EMBL:EHB16767.1};
KW Homeobox {ECO:0000313|EMBL:EHB16767.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT DOMAIN 178..270
FT /note="c-SKI SMAD4-binding"
FT /evidence="ECO:0000259|SMART:SM01046"
FT REGION 41..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 273..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 376..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 621..659
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 46..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..347
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..441
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..585
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 586..600
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHB16767.1"
SQ SEQUENCE 699 AA; 75095 MW; 54AE543BC345AFA3 CRC64;
MALLCGLGQV TFHLWVPLPS QSKNGIGXXX XFLRSGGMEA LTTQLGPGRE GSSSPNSKQE
LQPYSGSSAL KPNQVGETSL YGVPIVSLVI DGQERLCLAQ ISNTLLKNYS YNEIHNRRVA
LGITCVQCTP VQLEILRRAG AMPISSRRCG MITKREAERL CKSFLGEHKP PKLPENFAFD
VVHECAWGSR GSFIPARYNS SRAKCIKCGY CSMYFSPNKF IFHSHRTPDA KYTQPDAANF
NSWRRHLKLS DKSATDELSH AWEDVKAMFN GGTRKRTFSL QGGGGGANGG SGGQGKGNTG
GGGGPGCGAE MAPGPPPHKS LRCAEDEAAX LPPPLAPLQP PLPPPARKGS YVSAFRPVVK
DAESIAKLYG SAREAYGAGP APARAPGPGT GTGGGYVSPD FLSEGSSSYH SASPDVDTAD
EPEVDVESNR FPDEEGVQDE AESRAPSAPS AGGGPDGDQS AGPPSATSSG VDGPTDSPDD
SPAPRRRLGP PPGRSVFGDL AADDAVRRPE RSYESLAGPW EAQRRPRSGE RRSPGPARSA
PVQTGAAAAV ALGPAASYLC TREAHEPDKE DNHSTADDLE TRKSYSDQRS ISQPSPANTD
RGEEGLTLDV TGTQLVEKDI ENLAREELQK LLLEQMELRK KLEREFQSLK DNFQDQMKRE
LAYREEMVQQ LQIVRDTLCN ELDQERKARY AIQQKLKGA
//
