ID G5C810_HETGA Unreviewed; 628 AA.
AC G5C810;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Melanoma inhibitory activity protein 2 {ECO:0000313|EMBL:EHB17671.1};
GN ORFNames=GW7_07351 {ECO:0000313|EMBL:EHB17671.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB17671.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB17671.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004389}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
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DR EMBL; JH173777; EHB17671.1; -; Genomic_DNA.
DR AlphaFoldDB; G5C810; -.
DR STRING; 10181.G5C810; -.
DR eggNOG; ENOG502QUND; Eukaryota.
DR InParanoid; G5C810; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23158:SF38; MELANOMA INHIBITORY ACTIVITY PROTEIN 2; 1.
DR PANTHER; PTHR23158; MELANOMA INHIBITORY ACTIVITY-RELATED; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..628
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003475225"
FT DOMAIN 39..101
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 181..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 233..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 391..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 527..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..294
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..550
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 628 AA; 71619 MW; 67EEE0A964D06FCA CRC64;
MAEIGIHRLL LFVISLTEYL EGTKLLADLK KCGDLECETL ISRVLAVRDY TGPDCLYLNF
TKGEEISVYV KLAGEREDLW AGSKGKEFGF FPRDAVQIEE VFISEEVQIS TKESDFLCLL
GVSYMFENEH SDLNNDNSEN IYPYEEDRDL TYSIYESDFQ IKPVFYATPP STWFEDQFPA
SEAPEDIRSA SESNGWEEAE ASSVEQDHIP EVNYVSSPLP VREVQGRFGL GTEQAQEKAI
ESVTEPVQES SFRSRKIAVE DENDLEELNN GEPQTDHKRE PESEFESVPE EQPEQAHDLE
HILKPEATGW FGSGFISYLG FGEEDTGNLP LQDFPYSISS DEEATVPCTE MLTEKEDTIT
NDSSILKPSW FDFGFGVLSF AYANEDKIIS GDGKNEEDSG VNKHEHPHAS EFNSDKEEEI
KMIKIIETED QTEKEKVFEK TDDSDTMPYL KKFLYSFDSP WSFENIPKET ELPIPEQILD
QNYVVEREET EEFSLENYPT DNVKDLVMLD NRYSQSELSM RIHEAASFKT SSSKNNDEKS
KFPGDSEEPA QVEIDRSVEN TIPDSQMVST DNALSPHNYI PQKEDGSRFQ ILKYLFQIDI
CDVMTSVFSP IVLLSEWVSC SFKSFAIM
//