ID G5C860_HETGA Unreviewed; 279 AA.
AC G5C860;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Eukaryotic translation initiation factor 2 subunit 3 {ECO:0000313|EMBL:EHB17721.1};
GN ORFNames=GW7_16931 {ECO:0000313|EMBL:EHB17721.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB17721.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB17721.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
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DR EMBL; JH173792; EHB17721.1; -; Genomic_DNA.
DR AlphaFoldDB; G5C860; -.
DR STRING; 10181.G5C860; -.
DR InParanoid; G5C860; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR CDD; cd03688; eIF2_gamma_II; 1.
DR CDD; cd15490; eIF2_gamma_III; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015256; eIF2g_C.
DR InterPro; IPR044127; eIF2g_dom_2.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR PANTHER; PTHR42854; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER; 1.
DR PANTHER; PTHR42854:SF3; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED; 1.
DR Pfam; PF09173; eIF2_C; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|EMBL:EHB17721.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..279
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003475293"
FT DOMAIN 83..164
FT /note="Translation elongation factor EFTu-like"
FT /evidence="ECO:0000259|Pfam:PF03144"
FT DOMAIN 176..266
FT /note="Initiation factor eIF2 gamma C-terminal"
FT /evidence="ECO:0000259|Pfam:PF09173"
SQ SEQUENCE 279 AA; 29558 MW; 7E5242ED9C01AE92 CRC64;
MAAMLDGAAA TGAALLLIAG TVAEGAPIIP ISAQLKYNIE VVCEYIAKEI PVPPRDFTSE
PRLIVIRSFD VNKPGCEVDD LKGGVAGGST LKGVLKVGQE IEVRPGIVSK DSEGKLVCKP
IFSKTVSLFA EHNDLQYAAP GGLIGVGTKI DPTLCRAGRT VGQVLGAVGA LPEIVTELEI
SYFLLRRLLG VRTDGDKKAA KVQKLSKNEV LMVNIGSLST GGRVSAVKGD LGKIVLTNPV
CTEVGEKIAL SRRVEKHWRL IGWGQIRRGV TIKPTIDDD
//
