ID G5C873_HETGA Unreviewed; 784 AA.
AC G5C873;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Neural cell adhesion molecule 2 {ECO:0000313|EMBL:EHB17734.1};
GN ORFNames=GW7_07725 {ECO:0000313|EMBL:EHB17734.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB17734.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB17734.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
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DR EMBL; JH173800; EHB17734.1; -; Genomic_DNA.
DR AlphaFoldDB; G5C873; -.
DR STRING; 10181.G5C873; -.
DR eggNOG; KOG3510; Eukaryota.
DR InParanoid; G5C873; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR CDD; cd00063; FN3; 2.
DR CDD; cd00096; Ig; 1.
DR CDD; cd20970; IgI_1_MuSK; 1.
DR CDD; cd05866; IgI_1_NCAM-2; 1.
DR CDD; cd05870; IgI_NCAM-2; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR009138; Neural_cell_adh.
DR PANTHER; PTHR12231; CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN; 1.
DR PANTHER; PTHR12231:SF231; NEURAL CELL ADHESION MOLECULE 2; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF07679; I-set; 4.
DR Pfam; PF13927; Ig_3; 1.
DR PRINTS; PR01838; NCAMFAMILY.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 5.
DR SMART; SM00406; IGv; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 642..665
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..113
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 118..191
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 213..302
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 307..401
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 406..496
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 433..538
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 540..635
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 711..764
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 711..731
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 747..762
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 784 AA; 87500 MW; 73144F6967CF8DC7 CRC64;
MWFTHHSLQF IFKIRLIVTQ FFSALLQVTI SLSKVELSVG ESKFFTCTAI GEPESIDWYN
PQGEKIISTQ RVVVQKEVGR SRLTIYNANI EDAGIYRCQA TDAKGQTQEA TVVLEIYQKL
TFREVVSPQE FKQGEDAEVV CKVSSSPAPA VSWLYHNEEV TTISDNRFSV LANNNLQILN
INKSDEGIYR CEGRVEARGE IDFRDIIVIV NVPPAITMPQ KSFNATAERG EEMTLSCRAS
GSPEPTISWS RNGKIIEENE KYILKGSNTE LIVRNIINSD GGPYVCRATN KAGEDEKQAF
LQVFVQPHII QLKNETTYEN GHVTLICEAE GEPIPEISWK RAVDGITFSE GDKSSDGRIE
VRGQHGSSSL HIKDVKLSDS GRYDCEAASR IGGHQKSMYL DIEYAPKFIS NQTIYYSWEG
NPINISCDVK SNPPASIHWR REKLVLPAKN TTNLKTYTTG RKMILEIAPT SDNDFGRYNC
TATNRIGTRF QEYILALAAI VVLSNLEPNT TYEIRVAAVN GKGQGDYSKI EIFQTLPVRE
PSPPSIHGQP SSGKSFKISI TKQDDGGAPI LEYIVKYRSK DKEDQWLEKK VQGNKDHIIL
EHLQWTMGYE VQITAANRLG YSEPTVYEFS MPPKPNIIKD TLFNGLGLGA VIGLGVAALL
LILVVTDVSC FFIRQCGLLM CITRRICGKK SGSSGKSKEL EEGKAAYLKD GSKEPIVEMR
TEDERITNHE DGSPVNEPNE TTPLTEPEKL PLKEENGKEV LNPDTIEIKV SNDIIQSKED
DGKA
//
