ID G5CB95_HETGA Unreviewed; 821 AA.
AC G5CB95;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN ORFNames=GW7_05157 {ECO:0000313|EMBL:EHB18806.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB18806.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB18806.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; JH204765; EHB18806.1; -; Genomic_DNA.
DR AlphaFoldDB; G5CB95; -.
DR STRING; 10181.G5CB95; -.
DR eggNOG; KOG2177; Eukaryota.
DR eggNOG; KOG2995; Eukaryota.
DR InParanoid; G5CB95; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd11785; SH3_SH3RF_C; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 4.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035816; SH3RF1/SH3RF3_SH3_4.
DR PANTHER; PTHR14167:SF62; E3 UBIQUITIN-PROTEIN LIGASE SH3RF3; 1.
DR PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR Pfam; PF00018; SH3_1; 2.
DR Pfam; PF14604; SH3_9; 2.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 4.
DR SUPFAM; SSF50044; SH3-domain; 4.
DR PROSITE; PS50002; SH3; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 115..174
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 177..240
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 408..469
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 762..821
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 470..711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..645
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 646..661
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 672..688
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 821 AA; 87280 MW; BF052A71A9D4D455 CRC64;
MGCRAAKRGY MVAVGSEDAD QKAQAELDRD AQDPQGDWSA SSRDLSLNPD PGPPLDITWG
LASQEVSLVL HLEDESASSR DLSLNPDPGP PLDITWGLAS QEVSLVLHLE DESLSQLPYG
KALYSYEGKE PGDLKFNKGD VIILRRRVDE HWFHGELHGT RGFLPASYVQ CLRPLPQAPP
QGTALYDFEM KDRDQDQDCL TFTKDEVLTV IRRVDDNWAE GMLGDRIGIF PLLYVQHRPG
FSILLLKMRT YHMNTNCQLN DSAKQLIEMD KLCPAAAAAS SCAVPLPSDA STVASAGLGP
TAGSSGAVSA FQRRMDSKKN AKKRHSFTAL SVTHKSSQAV THRHSMEISA PVLISSSDPR
AAARIGELTH PPCSMPAQDP CSAGPVPTAV PRASTAAGEQ GTSPKVPLPL NVYLALYAYK
PQKSDELELR KGEMYRVLEK CQDGWFKGAS MRTGLSGVFP GNYVTPISRA PGGAAGPPRN
SALGGSPLAK GMATTMHPGG GSLSRPALPL TTPQAQAPHP AGSPPTGSCP HHTAQPATGQ
TRGALSAAAH PSAQAQDRPT ATVTPLRTQS SPSRLPTTSL RPRSMVSPQP GQQSPVQTSP
RPAIPFTSAA SAITPPSVST TSLSGDAGGG SSGGLSTSSP TSTGCRLEDK RGEKKEKKSG
LLKLLAGAST RRKSRSPPSF SPTHDPLVAT DTSLLGATGP DMSSLSVHGR AGSCPIESEM
RGAMGLEPLH RKTGSLDLNF CSSPARQAAL STAAIRPEPK PLPRERYRVV VSYPPQSEAE
IELKEGDVVF VHRKRKDGWY EGTLQRNGRT GLFPGSFVES F
//
