ID   G5CU43_PTEVA            Unreviewed;       410 AA.
AC   G5CU43;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   RecName: Full=von Willebrand factor {ECO:0000256|ARBA:ARBA00016619};
DE   Flags: Fragment;
GN   Name=vWF {ECO:0000313|EMBL:AEQ16327.1};
OS   Pteropus vampyrus (Large flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC   Pteropodinae; Pteropus.
OX   NCBI_TaxID=132908 {ECO:0000313|EMBL:AEQ16327.1};
RN   [1] {ECO:0000313|EMBL:AEQ16327.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=21961908; DOI=10.1186/1471-2148-11-281;
RA   Almeida F.C., Giannini N.P., DeSalle R., Simmons N.B.;
RT   "Evolutionary relationships of the old world fruit bats (Chiroptera,
RT   Pteropodidae): another star phylogeny?";
RL   BMC Evol. Biol. 11:281-281(2011).
CC   -!- SUBUNIT: Multimeric. Interacts with F8.
CC       {ECO:0000256|ARBA:ARBA00025858}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR   EMBL; JN398278; AEQ16327.1; -; Genomic_DNA.
DR   AlphaFoldDB; G5CU43; -.
DR   TreeFam; TF300299; -.
DR   GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR   CDD; cd01450; vWFA_subfamily_ECM; 2.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR   InterPro; IPR032361; VWA_N2.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR22588:SF5; COLLAGEN ALPHA-6(VI) CHAIN; 1.
DR   PANTHER; PTHR22588; UNCHARACTERIZED; 1.
DR   Pfam; PF00092; VWA; 2.
DR   Pfam; PF16164; VWA_N2; 1.
DR   PRINTS; PR00453; VWFADOMAIN.
DR   SMART; SM00327; VWA; 2.
DR   SUPFAM; SSF53300; vWA-like; 2.
DR   PROSITE; PS50234; VWFA; 2.
PE   4: Predicted;
KW   Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT   DOMAIN          39..215
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   DOMAIN          260..410
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..23
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AEQ16327.1"
FT   NON_TER         410
FT                   /evidence="ECO:0000313|EMBL:AEQ16327.1"
SQ   SEQUENCE   410 AA;  45750 MW;  6A536CC73E897151 CRC64;
     EPGGLDVPPT EVPGSPTTPY VEDTPEPPLH DFYCSKLLDL VFLLDGSNKL SEAEFEVLKV
     FVVGMMERLH ISQKRIRVAV VEYHDGSHAY LELRERKRPS ELRRIASQVK YAGSSVASTS
     EVLKYTLFQI FSKIDRPKAS RIVLLLTASQ EPPKLARNLV RYVQGLKKKK VIVVPVGIGP
     HANLKQIRLI EKQAPENKAF VLSGVDELEQ RRDEIISYLC DLAPEVPGPT QPPPVAQVTM
     GPELLGVLSE GPKRNSMVLD VVFVLEGSDK IGEANFNRSK EFMEEVIQRM DVSQDSIHVM
     VLQYSYVVTV ESTFLEAQSK EDILQRVREI RYRGGNRTNT GLALQYLSEH SFSASQGDRE
     QAPNLVYMVT GNPASDEIKR MPGDIQVVPI GVGPQADVQE LERIGWPNAP
//