ID G5CZ09_CAPMR Unreviewed; 392 AA.
AC G5CZ09;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=von Willebrand factor {ECO:0000256|ARBA:ARBA00016619};
DE Flags: Fragment;
GN Name=vWF {ECO:0000313|EMBL:AEP18863.1};
OS Caperea marginata (Pigmy right whale) (Balaena marginata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Neobalaenidae; Caperea.
OX NCBI_TaxID=27604 {ECO:0000313|EMBL:AEP18863.1};
RN [1] {ECO:0000313|EMBL:AEP18863.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21940861; DOI=10.1126/science.1211028;
RA Meredith R.W., Janecka J.E., Gatesy J., Ryder O.A., Fisher C.A.,
RA Teeling E.C., Goodbla A., Eizirik E., Simao T.L., Stadler T., Rabosky D.L.,
RA Honeycutt R.L., Flynn J.J., Ingram C.M., Steiner C., Williams T.L.,
RA Robinson T.J., Burk-Herrick A., Westerman M., Ayoub N.A., Springer M.S.,
RA Murphy W.J.;
RT "Impacts of the Cretaceous Terrestrial Revolution and KPg extinction on
RT mammal diversification.";
RL Science 334:521-524(2011).
CC -!- SUBUNIT: Multimeric. Interacts with F8.
CC {ECO:0000256|ARBA:ARBA00025858}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR EMBL; JN415036; AEP18863.1; -; Genomic_DNA.
DR AlphaFoldDB; G5CZ09; -.
DR GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR CDD; cd01450; vWFA_subfamily_ECM; 2.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR InterPro; IPR032361; VWA_N2.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR22588:SF5; COLLAGEN ALPHA-6(VI) CHAIN; 1.
DR PANTHER; PTHR22588; UNCHARACTERIZED; 1.
DR Pfam; PF00092; VWA; 2.
DR Pfam; PF16164; VWA_N2; 1.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00327; VWA; 2.
DR SUPFAM; SSF53300; vWA-like; 2.
DR PROSITE; PS50234; VWFA; 2.
PE 4: Predicted;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 40..216
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 241..386
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEP18863.1"
FT NON_TER 392
FT /evidence="ECO:0000313|EMBL:AEP18863.1"
SQ SEQUENCE 392 AA; 43478 MW; 54AD3F6C40B32DF7 CRC64;
REPGGLAVPP TEGPVGFTTP YVEDTPEPPL HDFFCSKLLD LVFLLDGSSK LSEADFETVK
AFVVGVMERL HISQKRIRVA VVEYHDGSHA YVALQDRKRP SELRRIAGQV KYAGSEVAST
SEVLKYTLFQ IFNKVDRPEA SRVALLLTAS QEPPRLARNL VRYVQGLRKK KVVMVPVGIG
PHAGLRQIRL IEKQAPENRA FVLSAAEELE QRRDEIVSYL CGLGPEAPAL AQRPLTARVL
DVAFLLEGSD SVGEAGFNRS AEFLEEVIRQ MDVGRDGVHV TVLQYSYVVT VEHSFRAGQS
KEDVLQRLRE IRHRGGNRTN TGLALRYLSE HSFSASQGDR EQAPNLVYMV TGSPASDEIR
RMPGDIQVVP IGVGPRVDVQ ELEKIGWPQA PI
//
