ID G5CZ23_PROLO Unreviewed; 412 AA.
AC G5CZ23;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=von Willebrand factor {ECO:0000256|ARBA:ARBA00016619};
DE Flags: Fragment;
GN Name=vWF {ECO:0000313|EMBL:AEP18877.1};
OS Procyon lotor (Raccoon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Procyonidae;
OC Procyon.
OX NCBI_TaxID=9654 {ECO:0000313|EMBL:AEP18877.1};
RN [1] {ECO:0000313|EMBL:AEP18877.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21940861; DOI=10.1126/science.1211028;
RA Meredith R.W., Janecka J.E., Gatesy J., Ryder O.A., Fisher C.A.,
RA Teeling E.C., Goodbla A., Eizirik E., Simao T.L., Stadler T., Rabosky D.L.,
RA Honeycutt R.L., Flynn J.J., Ingram C.M., Steiner C., Williams T.L.,
RA Robinson T.J., Burk-Herrick A., Westerman M., Ayoub N.A., Springer M.S.,
RA Murphy W.J.;
RT "Impacts of the Cretaceous Terrestrial Revolution and KPg extinction on
RT mammal diversification.";
RL Science 334:521-524(2011).
CC -!- SUBUNIT: Multimeric. Interacts with F8.
CC {ECO:0000256|ARBA:ARBA00025858}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR EMBL; JN415050; AEP18877.1; -; Genomic_DNA.
DR AlphaFoldDB; G5CZ23; -.
DR GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR CDD; cd01450; vWFA_subfamily_ECM; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR InterPro; IPR032361; VWA_N2.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR22588:SF5; COLLAGEN ALPHA-6(VI) CHAIN; 1.
DR PANTHER; PTHR22588; UNCHARACTERIZED; 1.
DR Pfam; PF00092; VWA; 2.
DR Pfam; PF16164; VWA_N2; 1.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00327; VWA; 2.
DR SUPFAM; SSF53300; vWA-like; 2.
DR PROSITE; PS50234; VWFA; 2.
PE 4: Predicted;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 40..216
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 261..412
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEP18877.1"
FT NON_TER 412
FT /evidence="ECO:0000313|EMBL:AEP18877.1"
SQ SEQUENCE 412 AA; 45567 MW; 609152101BAB22D6 CRC64;
REPGGLAVPP TDGPGGSTTP YVEDTSEPPL HDFSCSRLLD LVFLLDGSSK LSEGEFEVLK
GFVVGMMERL HISQKRIRVA LVEYHKGSHA YIDLQDRKRP SELQRITSQL KYVGSEVAST
SEVLKYTLFQ IFGRIDRPEA SRIALLLMAS QEPPRLARNL IRYVQGLKKK KVIVIPVGIG
PHANLKQIRN IEKQAPENKA FVLSSVDELE QRRDEIINYL CDLAPEPPGP TQQSPVAPVT
VGPELLGVPS SGPKRNPMAL DVVFVLEGSD KVGEANFNKS REFMEEVIRR MDVGQDSIHV
TVLQYSYAVA VEYTFSGAQS KGEVLQHVRE IRFRGGNRTN TGLVLQYLSD HSFSVSQGAR
EQVPNLVYMV TGNPASDEIK RMPGDIQVVP IGVGPHADAQ ELERISWPSA PI
//
