ID G5CZ40_TAPIN Unreviewed; 413 AA.
AC G5CZ40;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=von Willebrand factor {ECO:0000256|ARBA:ARBA00016619};
DE Flags: Fragment;
GN Name=vWF {ECO:0000313|EMBL:AEP18894.1};
OS Tapirus indicus (Asiatic tapir) (Malayan tapir).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Tapiridae; Tapirus.
OX NCBI_TaxID=9802 {ECO:0000313|EMBL:AEP18894.1};
RN [1] {ECO:0000313|EMBL:AEP18894.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21940861; DOI=10.1126/science.1211028;
RA Meredith R.W., Janecka J.E., Gatesy J., Ryder O.A., Fisher C.A.,
RA Teeling E.C., Goodbla A., Eizirik E., Simao T.L., Stadler T., Rabosky D.L.,
RA Honeycutt R.L., Flynn J.J., Ingram C.M., Steiner C., Williams T.L.,
RA Robinson T.J., Burk-Herrick A., Westerman M., Ayoub N.A., Springer M.S.,
RA Murphy W.J.;
RT "Impacts of the Cretaceous Terrestrial Revolution and KPg extinction on
RT mammal diversification.";
RL Science 334:521-524(2011).
CC -!- SUBUNIT: Multimeric. Interacts with F8.
CC {ECO:0000256|ARBA:ARBA00025858}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR EMBL; JN415067; AEP18894.1; -; Genomic_DNA.
DR GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR CDD; cd01450; vWFA_subfamily_ECM; 2.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR InterPro; IPR032361; VWA_N2.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR22588:SF5; COLLAGEN ALPHA-6(VI) CHAIN; 1.
DR PANTHER; PTHR22588; UNCHARACTERIZED; 1.
DR Pfam; PF00092; VWA; 2.
DR Pfam; PF16164; VWA_N2; 1.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00327; VWA; 2.
DR SUPFAM; SSF53300; vWA-like; 2.
DR PROSITE; PS50234; VWFA; 2.
PE 4: Predicted;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 40..216
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 261..413
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEP18894.1"
FT NON_TER 413
FT /evidence="ECO:0000313|EMBL:AEP18894.1"
SQ SEQUENCE 413 AA; 46267 MW; DE98FE9214B62A9B CRC64;
QDPEGLVVPP TEGPVSPTTA YVEDTPEPPL HDFYCSKLLD LVFLLDGSSK LSEAEFEVLK
AFVVGMMERL HISQKRIRVA VVEYHDGSHA YIALRDRKRP SELRRIASQV KYAGSEVAST
SEVLKYTLFQ IFGKIDRPEA SRITLLLMAS QEPPRLARNL VRYVQGLKKK KVIVIPVGIG
PHANLKQIRL IEKQAPENKA FVLSGVDELE QQRDEIISYL CDLAPEPPAP TQRPRTAQVT
VSPELSGGLS QGHKRNSMVL DVVFVLEGSD KIGEANFNRS REFMEEVIQR MDVGQHNIHI
TVLQYSYXVT VEYTFLETQS KKDVLQRVRE IRYQGGNRTN TGLALQYLAE HSFLAGQGDR
EQAPNLVYMV TGNPASDEIK RMPGDIQVVP IGVGPRANVQ ELERIGWPNA PIL
//
