ID G5E1F3_9PIPI Unreviewed; 92 AA.
AC G5E1F3;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Complement component C8 beta chain {ECO:0000256|ARBA:ARBA00013949};
DE AltName: Full=Complement component 8 subunit beta {ECO:0000256|ARBA:ARBA00031383};
DE Flags: Fragment;
OS Pipa carvalhoi (Carvalho's Surinam toad).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Pipinae; Pipa.
OX NCBI_TaxID=191480 {ECO:0000313|EMBL:AEQ16980.1};
RN [1] {ECO:0000313|EMBL:AEQ16980.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Liver {ECO:0000313|EMBL:AEQ16980.1};
RA Chain F.J.J., Evans B.J., Dushoff J.;
RT "The odds of duplicate gene persistence after polyploidization.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Constituent of the membrane attack complex (MAC) that plays a
CC key role in the innate and adaptive immune response by forming pores in
CC the plasma membrane of target cells. {ECO:0000256|ARBA:ARBA00002409}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; JP287217; AEQ16980.1; -; mRNA.
DR AlphaFoldDB; G5E1F3; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005579; C:membrane attack complex; IEA:UniProtKB-KW.
DR GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR001862; MAC_perforin.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR45742; COMPLEMENT COMPONENT C6; 1.
DR PANTHER; PTHR45742:SF5; COMPLEMENT COMPONENT C8 BETA CHAIN; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR PRINTS; PR00764; COMPLEMENTC9.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00209; TSP1; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS50092; TSP1; 1.
PE 2: Evidence at transcript level;
KW Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Membrane attack complex {ECO:0000256|ARBA:ARBA00023058}.
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEQ16980.1"
FT NON_TER 92
FT /evidence="ECO:0000313|EMBL:AEQ16980.1"
SQ SEQUENCE 92 AA; 10302 MW; ECD5CA5D1DBB6ED8 CRC64;
PVDCALSSWS AWGSCDPCQK KRYRYARLTQ PSQFRGDPCD SIDRQVESCV SSSPCRNIKR
CEGFQCAETG RCIARRLLCN GDDDCGDLSD EK
//
