ID G5E2G7_9PIPI Unreviewed; 83 AA.
AC G5E2G7;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Diphthamide biosynthesis protein 3 {ECO:0000256|ARBA:ARBA00041070};
DE AltName: Full=CSL-type zinc finger-containing protein 2 {ECO:0000256|ARBA:ARBA00041904};
DE Flags: Fragment;
OS Hymenochirus curtipes (western dwarf clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Pipinae; Hymenochirus.
OX NCBI_TaxID=8362 {ECO:0000313|EMBL:AEQ18378.1};
RN [1] {ECO:0000313|EMBL:AEQ18378.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Liver {ECO:0000313|EMBL:AEQ18378.1};
RA Chain F.J.J., Evans B.J., Dushoff J.;
RT "The odds of duplicate gene persistence after polyploidization.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-
CC 4S](1+)-[protein] + 2 [Dph3] + H(+) + NAD(+); Xref=Rhea:RHEA:71239,
CC Rhea:RHEA-COMP:17997, Rhea:RHEA-COMP:17998, Rhea:RHEA-COMP:18001,
CC Rhea:RHEA-COMP:18002, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033,
CC ChEBI:CHEBI:33723, ChEBI:CHEBI:47402, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945, ChEBI:CHEBI:83228;
CC Evidence={ECO:0000256|ARBA:ARBA00036715};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein]
CC + Fe(3+)-[Dph3]; Xref=Rhea:RHEA:71235, Rhea:RHEA-COMP:17996,
CC Rhea:RHEA-COMP:17997, Rhea:RHEA-COMP:18002, Rhea:RHEA-COMP:18003,
CC ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:33751,
CC ChEBI:CHEBI:47402, ChEBI:CHEBI:83228;
CC Evidence={ECO:0000256|ARBA:ARBA00036267};
CC -!- PATHWAY: Protein modification; peptidyl-diphthamide biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005156}.
CC -!- SIMILARITY: Belongs to the DPH3 family.
CC {ECO:0000256|ARBA:ARBA00024032}.
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DR EMBL; JP287581; AEQ18378.1; -; mRNA.
DR AlphaFoldDB; G5E2G7; -.
DR Gene3D; 3.10.660.10; DPH Zinc finger; 1.
DR InterPro; IPR007872; DPH_MB_dom.
DR InterPro; IPR036671; DPH_MB_sf.
DR PANTHER; PTHR21454:SF31; DPH3 HOMOLOG; 1.
DR PANTHER; PTHR21454; DPH3 HOMOLOG-RELATED; 1.
DR Pfam; PF05207; zf-CSL; 1.
DR SUPFAM; SSF144217; CSL zinc finger; 1.
DR PROSITE; PS51074; DPH_MB; 1.
PE 2: Evidence at transcript level;
FT DOMAIN 4..60
FT /note="DPH-type MB"
FT /evidence="ECO:0000259|PROSITE:PS51074"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEQ18378.1"
FT NON_TER 83
FT /evidence="ECO:0000313|EMBL:AEQ18378.1"
SQ SEQUENCE 83 AA; 9449 MW; 2C65FBE7E5C0ECC6 CRC64;
MSVFHDEVEI EDFEYDEDTE TYYYPCPCGD RFAITKEDLE NGEEVATCPS CSLIVKVIYD
KDEFMHGEVI AEPVASKPGL LKC
//
