ID G5E5W4_BOVIN Unreviewed; 1308 AA.
AC G5E5W4;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Contactin associated protein family member 4 {ECO:0000313|Ensembl:ENSBTAP00000036729.5};
GN Name=CNTNAP4 {ECO:0000313|Ensembl:ENSBTAP00000036729.5,
GN ECO:0000313|VGNC:VGNC:27541};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000036729.5, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000036729.5, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000036729.5,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000036729.5}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000036729.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the neurexin family.
CC {ECO:0000256|ARBA:ARBA00010241}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; NP_001193440.1; NM_001206511.1.
DR SMR; G5E5W4; -.
DR STRING; 9913.ENSBTAP00000036729; -.
DR PaxDb; 9913-ENSBTAP00000036729; -.
DR Ensembl; ENSBTAT00000036878.5; ENSBTAP00000036729.5; ENSBTAG00000026004.5.
DR GeneID; 536775; -.
DR KEGG; bta:536775; -.
DR CTD; 85445; -.
DR VEuPathDB; HostDB:ENSBTAG00000026004; -.
DR VGNC; VGNC:27541; CNTNAP4.
DR eggNOG; KOG3516; Eukaryota.
DR GeneTree; ENSGT00940000157674; -.
DR HOGENOM; CLU_003504_1_0_1; -.
DR InParanoid; G5E5W4; -.
DR OMA; LSTQNWS; -.
DR OrthoDB; 4255614at2759; -.
DR TreeFam; TF321823; -.
DR Proteomes; UP000009136; Chromosome 18.
DR Bgee; ENSBTAG00000026004; Expressed in occipital lobe and 51 other cell types or tissues.
DR ExpressionAtlas; G5E5W4; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00057; FA58C; 1.
DR CDD; cd00110; LamG; 4.
DR Gene3D; 2.60.120.1000; -; 1.
DR Gene3D; 2.60.120.200; -; 4.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR001791; Laminin_G.
DR NCBIfam; NF040941; GGGWT_bact; 1.
DR PANTHER; PTHR15036:SF40; CONTACTIN-ASSOCIATED PROTEIN-LIKE 4; 1.
DR PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF02210; Laminin_G_2; 4.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00231; FA58C; 1.
DR SMART; SM00282; LamG; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01285; FA58C_1; 1.
DR PROSITE; PS01286; FA58C_2; 1.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 4.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00122}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1308
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018615103"
FT TRANSMEM 1241..1265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..177
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT DOMAIN 183..364
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 370..547
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 549..586
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 585..640
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51406"
FT DOMAIN 793..958
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 959..997
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1017..1202
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 1206..1231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1214..1231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 931..958
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
SQ SEQUENCE 1308 AA; 144880 MW; 38841A5C433984A6 CRC64;
MGSVTGAVLK TLLLLSTPNW NRVLAGNSYN CDDPLVSTLS QASFSSSSEL SSSHGPGFAR
LNRRDGAGGW SPLVSNKYQW LQIDLGERME ITAVATQGGY GSSNWVTSYL LMFSDSGRNW
KQYRQEDSIW GFVGNANADS VVYYRLQPSI KARFLRFIPL EWNPKGRIGM RIEVFGCAYR
SEVVDLDGKS CLLYRFDQKS LSPIKDVISL KFKTMQSDGI LLHREGQNGD HITLELRRGK
LFLLINSGDA KPPSARAPVR LTLGSLLDDQ HWHSVLIQRL GTQVNFTVDG HRRRFRAQGE
FSSLHLDYEI SFGGIPAPGK PVSFPHKHFH GCLENLFYDG VDIIDLAKRQ DPQMIVMGNV
SFSCSQPQSV PVTFLSPRSY LALPGSFGED EISATFQFRT WNKAGLLLFT ELQLVSGGLL
LFLNDGKLKL HLYHPGKLPS DITAGVGLND GQWHSVSLSA KRNYLSVVVD GQVASASPSQ
GPEQIYSGGI FYFGGCPDSS FGSKCKSPLG GFQGCMRLIS IRHEVVDLIS LQPGALGNFS
DLQIDSCGIT DRCLPNYCEH GGECSQSWDT FHCNCANTGY RGATCHNSIY EQSCEAYKHK
GNTSGFYYID ADGSGPLEPF LLYCNMTETA WTIIQHNGSG VTRVRNTNPE NPYTGFFEYV
ASMEQLQATI NRAEHCEQEL TYYCKKSRLV SKEDGAPLSW WVGRTNETQT YWGGSLPDPQ
KCTCGLEGNC VDSQYYCNCD ADRNEWTNDT GFLSYKEHLP VTRIVITDTG RPHSEAAYKL
GPLLCRGDKL FWNSASFNTE ASYLHFPTFH GELSADVSFF FKTTASSGVF LENLGITDFI
RIELRSPAVV TFSFDVGNGP FEISVQSPTH FSDNQWHHVR VERNMKEASV RVDQLSPKTQ
PAPADGHVLL QLNSQLFVGG TATRQRGFLG CIRSLQLNGE ALDLEERARV TPGVEPGCRG
HCSSYGRLCH HGGMCMEKPS GFSCDCTSSA YAGPFCSDEI SAYFGSGSSV IYNFQENYSL
SKNSSSHAAS FHGDTRLSRE TIKFSFRTTR TPSLLLYLSS FYKEYLSVIL AKNGSLQIRY
KLNRYQEPDV VNFDFKNMAD GQLHHVKINR EEAVVFVEID ESMRRQVHLA SGTELSAVRS
LVLGRIIEHS DVDQETALAG AQGFLGCLSA VQVSHVAPLK AALQPSRPAP ITVSGHVTES
SCVAQAGTDA TSRERTHSFA DHSGTRDDRE PLTKTIKSDS AVIGGLIAVV IFILLCIAAI
AVRIYQQKRL YKRNEAKRSE NVDNAEAVLK SELNIQNPVK ENQKEYFF
//
