ID G5EBZ2_CAEEL Unreviewed; 904 AA.
AC G5EBZ2;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 77.
DE SubName: Full=Cysteine-rich motor neuron 1 protein {ECO:0000313|EMBL:CAD44089.2};
GN Name=crm-1 {ECO:0000313|EMBL:CAD44089.2,
GN ECO:0000313|WormBase:B0024.14d};
GN ORFNames=B0024.14 {ECO:0000313|WormBase:B0024.14d}, CELE_B0024.14
GN {ECO:0000313|EMBL:CAD44089.2};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAD44089.2, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAD44089.2, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAD44089.2,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
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DR EMBL; BX284605; CAD44089.2; -; Genomic_DNA.
DR RefSeq; NP_741618.2; NM_171935.4.
DR AlphaFoldDB; G5EBZ2; -.
DR SMR; G5EBZ2; -.
DR EnsemblMetazoa; B0024.14d.1; B0024.14d.1; WBGene00007103.
DR GeneID; 179439; -.
DR AGR; WB:WBGene00007103; -.
DR WormBase; B0024.14d; CE42520; WBGene00007103; crm-1.
DR OrthoDB; 2946817at2759; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00007103; Expressed in larva and 4 other cell types or tissues.
DR ExpressionAtlas; G5EBZ2; baseline and differential.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR Gene3D; 6.20.200.20; -; 6.
DR InterPro; IPR004094; Antistasin-like.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR46439; CYSTEINE-RICH MOTOR NEURON 1 PROTEIN; 1.
DR PANTHER; PTHR46439:SF1; CYSTEINE-RICH MOTOR NEURON 1 PROTEIN; 1.
DR Pfam; PF02822; Antistasin; 3.
DR Pfam; PF00093; VWC; 4.
DR SMART; SM00214; VWC; 7.
DR SUPFAM; SSF57603; FnI-like domain; 6.
DR PROSITE; PS51252; ANTISTASIN; 3.
DR PROSITE; PS01208; VWFC_1; 3.
DR PROSITE; PS50184; VWFC_2; 6.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|EPD:G5EBZ2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..904
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003475837"
FT TRANSMEM 767..788
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 195..254
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 251..312
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 323..349
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 360..388
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 391..417
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 448..513
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 533..593
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 608..669
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 676..732
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT REGION 843..904
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 843..862
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 863..892
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 904 AA; 99010 MW; 1ACDF37BAD4AEF3C CRC64;
MQLVVCVFLL LFSFVNFLRT EQSERMHDDC LKAICPLVFH KGCPSDSQLI TVSPAPGNCC
PPPGSCHCDQ KKCVPSVPTC TKEERLVMVE KGSDIPGKCC AYYECHKKEK KCENVHCPPM
FQDEEECPPD SIRPPESISK ESCCPIRQSC KCRGSICRPA QCPDGKVVNV TKKGTGFPGR
CCDKWECVDA ELSKAKCNHS GIERQPLETW HVSDCESCQC IRGVSVCNKM TCPKVNQECT
WIGIPTGECC PVCLGCQTDN QTKLERGATW QKDDCTSCTC SELGAHMCEK YMCKTDCENP
RKVEGQCCPV CDEPTIIRPP ATCPSLELCS LRCANGLRRD NIGCYVCECL PDEVPTNPRC
RELNDENCEK QCAHGYLKDE DGCTVCKCSK CPPLHQCHKH CLYGFETNSA GCSLCKCRAS
SKLDKKQGTT KSTKLGAGSA QQTEYHSEKC ISFSNDGHQI VRDGGEWWSD GCRHCFCENK
QEFCSLISCP TKPSDCADEK WVQKEDECCP SCIDQKKKPK SSNSLAAQKH EHTVCQSPGT
GRLFTDGETW QLAPCVSCTC RVGHVLCRTT ECPPIACPNP EYQNEEDCCP TCPEQKVENT
KNEKGDTIVC TDDAGTAHIV GSSWRQDDCT SCVCSAEGSA DCYKEACDES LECRGNPLVI
KGKCCPVCSD ALSSSAVCSY QSSVYAIGEQ WQDGRCSNCS CVTGGQTVCR QMVCPHCDDP
VPIEGHCCPL CKDAKWSPYG YGNGSASFPT SLGPRVDDGN GSSATSLIVV SLMSLCVVAL
IIVLMLLYKR NKKSNKVQFQ LHKFNEVGQI ASGGASTVRL SASKTIGSMP RLVDWKDTRE
ESTEELLKTS TNHVRHDSQN SDDQSDSLLS TMSDTSTAPS TISSSGHVPI SDTQPLTPKH
RYPV
//
