ID G5ECC3_CAEEL Unreviewed; 791 AA.
AC G5ECC3;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 2.
DT 27-MAR-2024, entry version 101.
DE SubName: Full=Dynamin-type G domain-containing protein {ECO:0000313|EMBL:CCD72159.2};
GN Name=rme-1 {ECO:0000313|EMBL:CCD72159.2,
GN ECO:0000313|WormBase:W06H8.1b};
GN ORFNames=CELE_W06H8.1 {ECO:0000313|EMBL:CCD72159.2}, W06H8.1
GN {ECO:0000313|WormBase:W06H8.1b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD72159.2, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD72159.2, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD72159.2,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004125}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004125}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004125}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR EMBL; BX284605; CCD72159.2; -; Genomic_DNA.
DR AlphaFoldDB; G5ECC3; -.
DR SMR; G5ECC3; -.
DR IntAct; G5ECC3; 1.
DR STRING; 6239.W06H8.1b.2; -.
DR EPD; G5ECC3; -.
DR PeptideAtlas; G5ECC3; -.
DR EnsemblMetazoa; W06H8.1b.1; W06H8.1b.1; WBGene00004373.
DR AGR; WB:WBGene00004373; -.
DR WormBase; W06H8.1b; CE52145; WBGene00004373; rme-1.
DR HOGENOM; CLU_017595_3_0_1; -.
DR InParanoid; G5ECC3; -.
DR OrthoDB; 12127at2759; -.
DR PhylomeDB; G5ECC3; -.
DR Reactome; R-CEL-983231; Factors involved in megakaryocyte development and platelet production.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00004373; Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues.
DR ExpressionAtlas; G5ECC3; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR GO; GO:0030139; C:endocytic vesicle; IBA:GO_Central.
DR GO; GO:0012505; C:endomembrane system; IDA:WormBase.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0055037; C:recycling endosome; IDA:WormBase.
DR GO; GO:0055038; C:recycling endosome membrane; IDA:UniProtKB.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IDA:WormBase.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0019904; F:protein domain specific binding; IPI:WormBase.
DR GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR GO; GO:0032456; P:endocytic recycling; IMP:WormBase.
DR GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR GO; GO:0060990; P:lipid tube assembly involved in organelle fission; IDA:WormBase.
DR GO; GO:0070266; P:necroptotic process; IGI:WormBase.
DR GO; GO:1904950; P:negative regulation of establishment of protein localization; IMP:UniProtKB.
DR GO; GO:0072659; P:protein localization to plasma membrane; IBA:GO_Central.
DR CDD; cd00052; EH; 1.
DR CDD; cd09913; EHD; 1.
DR Gene3D; 1.10.268.20; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR040990; DUF5600.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR000261; EH_dom.
DR InterPro; IPR031692; EHD_N.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11216; EH DOMAIN; 1.
DR PANTHER; PTHR11216:SF161; EPIDERMAL GROWTH FACTOR RECEPTOR PATHWAY SUBSTRATE CLONE 15, ISOFORM A; 1.
DR Pfam; PF18150; DUF5600; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF12763; EF-hand_4; 1.
DR Pfam; PF16880; EHD_N; 1.
DR SMART; SM00027; EH; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50031; EH; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|EPD:G5ECC3,
KW ECO:0007829|PeptideAtlas:G5ECC3};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT DOMAIN 286..517
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT DOMAIN 689..777
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 721..756
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 58..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 632..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 765..791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..79
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..133
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 791 AA; 89250 MW; 7023F62125C812A5 CRC64;
MESVNSEEHK INEAPAPPVI VINSSTKEEQ EATQTDRIEG QMKKIDSVFD EQNVASLEGV
NSKNEISGSV SSSSFEELNA ETEDLSERSE VEKDEDLGRV VEEHKEPAQV PVESETPETS
KKEIHQEEEI SELEKVPETV EEEIEVVNTS VEITEVKKEV IEEVKISGLK EEETPVPKMR
AQQQVPVAAD RPIRRLSIAR ASMMTPKASP KLAKYMEPVR EEGQKKKKTR SMFSWLGGDS
SKKKNKEVLE TVSEGLRKIY KQKLLPLEEF HKFHDFHSPA LDDPDFDAKP MILLVGQYST
GKTTFIRYLL ESDFPGIRIG PEPTTDRFIA VMHGDEEGSI PGNALVVDAK KQFRALSGFG
NAFLNRFQCS TLPNQVLESV TIVDTPGILS GEKQRIDRGY DFTGVLEWFA ERVDRIILLF
DAHKLDISDE FKRCIEALAG NEDKIRIVLN KSDMVDHQQL MRVYGALMWS LGKVFKTPEV
SRVYLGSFWD HPLHYDLNRR LFQDEQHDLF QDLQALPRNA ALRKLNDLIK RARLAKVHAY
IIAELRKQMP SMIGKDKKKK DLIQNLDKIY EQLQREHNIS PGDFPDVNKM REKLQTQDFS
KFNPLKPKLL EVVDGMLATD IARLMAQIPK EEAAAPAGSN GSADPTVRGG AFSQTTEAET
PFGFGRYDAR WGEGFDKGAD EAEWVVSRER TTADSTFESL GPVNGYLSGR AAKEHMVKSK
LPNSVLGKVW KLADIDKDGQ LDADEFALAN YLINLKLEGH EIPSELPKHL IPPSKRGEQD
PVYPSLNDND E
//
