ID G5EE37_CAEEL Unreviewed; 622 AA.
AC G5EE37;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 104.
DE SubName: Full=Incenp-like protein ICP-1 {ECO:0000313|EMBL:AAG24400.1};
DE SubName: Full=Inner centromere protein ARK-binding domain-containing protein {ECO:0000313|EMBL:CCD69912.1};
GN Name=icp-1 {ECO:0000313|EMBL:CCD69912.1,
GN ECO:0000313|WormBase:Y39G10AR.13a};
GN ORFNames=CELE_Y39G10AR.13 {ECO:0000313|EMBL:CCD69912.1}, Y39G10AR.13
GN {ECO:0000313|WormBase:Y39G10AR.13a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:AAG24400.1};
RN [1] {ECO:0000313|EMBL:CCD69912.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD69912.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000313|EMBL:AAG24400.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11050385; DOI=10.1016/S0960-9822(00)00721-1;
RA Kaitna S., Mendoza M., Jantsch-Plunger V., Glotzer M.;
RT "Incenp and an aurora-like kinase form a complex essential for chromosome
RT segregation and efficient completion of cytokinesis.";
RL Curr. Biol. 10:1172-1181(2000).
RN [3] {ECO:0000313|EMBL:CCD69912.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD69912.1};
RA Sulson J.E., Waterston R.;
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:CCD69912.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD69912.1};
RG WormBase Consortium;
RA WormBase;
RL Submitted (AUG-2023) to the EMBL/GenBank/DDBJ databases.
CC -!- INTERACTION:
CC G5EE37; O01427: air-2; NbExp=4; IntAct=EBI-312981, EBI-312947;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|ARBA:ARBA00004186}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the INCENP family.
CC {ECO:0000256|ARBA:ARBA00010042}.
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DR EMBL; AF300704; AAG24400.1; -; mRNA.
DR EMBL; BX284601; CCD69912.1; -; Genomic_DNA.
DR RefSeq; NP_490956.1; NM_058555.8.
DR SMR; G5EE37; -.
DR ComplexPortal; CPX-3461; Chromosomal passenger complex.
DR IntAct; G5EE37; 1.
DR STRING; 6239.Y39G10AR.13a.2; -.
DR PaxDb; 6239-Y39G10AR-13-1; -.
DR EnsemblMetazoa; Y39G10AR.13a.1; Y39G10AR.13a.1; WBGene00002047.
DR GeneID; 171788; -.
DR KEGG; cel:CELE_Y39G10AR.13; -.
DR AGR; WB:WBGene00002047; -.
DR WormBase; Y39G10AR.13a; CE26991; WBGene00002047; icp-1.
DR eggNOG; KOG4456; Eukaryota.
DR OMA; SPMSNPK; -.
DR OrthoDB; 3094173at2759; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00002047; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR GO; GO:0005694; C:chromosome; IDA:UniProtKB.
DR GO; GO:0032133; C:chromosome passenger complex; IPI:ComplexPortal.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000776; C:kinetochore; IDA:WormBase.
DR GO; GO:0015630; C:microtubule cytoskeleton; IDA:ComplexPortal.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0030295; F:protein kinase activator activity; IDA:WormBase.
DR GO; GO:0043539; F:protein serine/threonine kinase activator activity; IDA:WormBase.
DR GO; GO:0007143; P:female meiotic nuclear division; IMP:UniProtKB.
DR GO; GO:0000278; P:mitotic cell cycle; IMP:UniProtKB.
DR GO; GO:0007079; P:mitotic chromosome movement towards spindle pole; IMP:WormBase.
DR GO; GO:0000281; P:mitotic cytokinesis; IMP:WormBase.
DR GO; GO:0007080; P:mitotic metaphase chromosome alignment; IMP:WormBase.
DR GO; GO:0090307; P:mitotic spindle assembly; IMP:UniProtKB.
DR GO; GO:0051256; P:mitotic spindle midzone assembly; NAS:ComplexPortal.
DR GO; GO:0098813; P:nuclear chromosome segregation; IMP:UniProtKB.
DR GO; GO:0090267; P:positive regulation of mitotic cell cycle spindle assembly checkpoint; NAS:ComplexPortal.
DR GO; GO:1901970; P:positive regulation of mitotic sister chromatid separation; NAS:ComplexPortal.
DR Gene3D; 6.10.250.2990; -; 1.
DR InterPro; IPR005635; Inner_centromere_prot_ARK-bd.
DR PANTHER; PTHR13142; INNER CENTROMERE PROTEIN; 1.
DR PANTHER; PTHR13142:SF1; INNER CENTROMERE PROTEIN; 1.
DR Pfam; PF03941; INCENP_ARK-bind; 1.
PE 1: Evidence at protein level;
KW Chromosome partition {ECO:0000256|ARBA:ARBA00022829};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteomics identification {ECO:0007829|EPD:G5EE37,
KW ECO:0007829|PeptideAtlas:G5EE37};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT DOMAIN 530..587
FT /note="Inner centromere protein ARK-binding"
FT /evidence="ECO:0000259|Pfam:PF03941"
FT REGION 88..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 435..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 599..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..487
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..528
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 601..622
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 622 AA; 69920 MW; 7E055664F8D38DEB CRC64;
MPPKKRAVSR KPAEPTIKLF SSIPKISSIF DEVSEAHDDA AAKVFADLYK RMSSITEELA
TPQFSAEQLL NAVLKPGRID AEFVELISRQ KAKPAQPSSS SHRGDDDMET DEVETDQAGP
ITPRAGSVAT DGDFEEDILP VTLKRMQQMS ISKKKTEGSI SRNAAYSGTP RRNPPREAHN
QATPRNIFSS TPGRMAGTPG RAAVVPRTPH RVIPFNDAEK DPNARMKHAD ELRMKELEKK
REKARKDEEK RNAVMERRKE QERVRQEKLD QLKQKEERNA NLAKLHNSAK SPTRARLMQD
HAPNKAASRK IFPTAESTST PGRGPAKKGK VEILIGSDGQ KTAPVAQPTV ELSPSRELQR
NGSRQVKMEP MSCDDSTPPA RQHKPKAKAT KRSAHAASSS TSNVEAAAAL AALQEQQRIQ
LEQEQYLLQL AEDERRKREQ KEMKEKAEKE RQLRAREEQE HFLAVQREEQ AQLEKQRERE
EAELQATLAR CAEKQARQEA LRKTPPPAAY EMTPPRTYQN NSKNDYGLND LNSDDETDQE
DDPRKDVPAW AEFAVVRENV RRHAINPPFD VAQFFGSIGK PNLKEIFSDA VKVKKRGSSA
VWKKSPSTLN TSSRTILQDI SE
//
