ID G5EF63_CAEEL Unreviewed; 971 AA.
AC G5EF63;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Sorting nexin-12 {ECO:0000313|EMBL:CAC70107.3};
GN Name=snx-14 {ECO:0000313|EMBL:CAC70107.3,
GN ECO:0000313|WormBase:Y48E1B.14a};
GN ORFNames=CELE_Y48E1B.14 {ECO:0000313|EMBL:CAC70107.3}, Y48E1B.14
GN {ECO:0000313|WormBase:Y48E1B.14a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAC70107.3, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAC70107.3, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAC70107.3,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; BX284602; CAC70107.3; -; Genomic_DNA.
DR RefSeq; NP_496844.3; NM_064443.5.
DR AlphaFoldDB; G5EF63; -.
DR SMR; G5EF63; -.
DR STRING; 6239.Y48E1B.14a.2; -.
DR EPD; G5EF63; -.
DR PaxDb; 6239-Y48E1B-14a; -.
DR PeptideAtlas; G5EF63; -.
DR EnsemblMetazoa; Y48E1B.14.1; Y48E1B.14.1; WBGene00013011.
DR GeneID; 174997; -.
DR KEGG; cel:CELE_Y48E1B.14; -.
DR AGR; WB:WBGene00013011; -.
DR WormBase; Y48E1B.14a; CE33876; WBGene00013011; snx-14.
DR eggNOG; KOG2101; Eukaryota.
DR GeneTree; ENSGT00950000182856; -.
DR HOGENOM; CLU_014115_0_0_1; -.
DR InParanoid; G5EF63; -.
DR OMA; YMFMQHI; -.
DR OrthoDB; 2877434at2759; -.
DR PhylomeDB; G5EF63; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00013011; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR ExpressionAtlas; G5EF63; baseline and differential.
DR GO; GO:0005770; C:late endosome; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IBA:GO_Central.
DR GO; GO:0097352; P:autophagosome maturation; IBA:GO_Central.
DR CDD; cd06877; PX_SNX14; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR037436; SNX14_PX.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR PANTHER; PTHR22775:SF44; SORTING NEXIN-14; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR Pfam; PF00615; RGS; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00313; PXA; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|EPD:G5EF63,
KW ECO:0007829|PeptideAtlas:G5EF63};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 112..314
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT DOMAIN 593..712
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 75..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 520..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 971 AA; 111183 MW; AFF7B52C0D18C4F3 CRC64;
MMNMSDPKQQ QQQKIHVGAA VVLLTAIFYA ADFGFVSILV VIGSLLAGIL FAKWVFECSN
GEMLYQWKDY FNPSATTSSR KPEAEEADDD DDDARLDSEK TRRMPWQGLS LPASLNEAVE
NLLNEIVEQY VNGWYGGAIS RDRAFINEIR YQLRYASANL IRCIRRVDLA EFVSDQALPI
ASFYITRINE LEQKLRESPT PPRSLLETKI AEQLDDIHVA LSGRDEETAY VRQISDFLIP
RLLDETRLAG RAHDDDSPLR LFGRGKNERP WPSKSVRGFL REMLTNAVLL PVFDMLTQPD
TINYWLILLF DEHRKVEMIE EHVDTTPIPL LKGLTDESGA SDNLPDSLLQ LKLTEILRDA
RLYAIFRMYL QDIRGPVHEL QFLVEATRIL DSIQRKLESD SQIAYDIWQL YGQFVHESAQ
ERVRIAESLV EQYKSAVEVN DIRVLEGIIE MSYQEVYNRT QSTHVVAFCQ SECFLGHLCG
SPPITINELI DQQARQRAAA PVERTFSLSQ LRARVRKALT SVSDEEKEEA GVETPESQGG
SSTASSYVNI AAPSIDVIED VEEERSEPAE EAPIPKTTGL VIDSEPPINL NCWKVNVAQV
NGLRDKISDR VIFVFIIEVE RPDAKPHETQ RWSIHRSFNE FYVLESKLNE FHGDSLRFSP
LPTRKTFVTR DKPFMEQHRL IFSTFLSTLS KQRILNRSEL LLAFLSSNEE FRDTLSLGDL
NPWKVVKKTL PGKLVNREKG QNLKPFLLKT LAQTLVPPDR VKKPSENGLE DATTSYSLAT
NAVYSSVYGN NFDGVFKESC RSLGDEDMRL WTRSAYDSIL LLFWQPLKTQ FQWALPIFSA
IRALCSKTID SMICSVLGGV FRKCLSVANL TYLVQHIQWS LFCNDAPWPT EQEMKMREEL
ALRITLEFFQ NNIPQHARRL IGRDDIKTLI SRIIDVLQYP RLNKQLLYVL VDRLLLQIFP
ELDEFGQHPL Q
//
