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Database: UniProt
Entry: G5EGP4_CAEEL
LinkDB: G5EGP4_CAEEL
Original site: G5EGP4_CAEEL 
ID   G5EGP4_CAEEL            Unreviewed;       865 AA.
AC   G5EGP4;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   27-SEP-2017, entry version 54.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=vha-6 {ECO:0000313|EMBL:CAA20334.1,
GN   ECO:0000313|WormBase:VW02B12L.1};
GN   ORFNames=CELE_VW02B12L.1 {ECO:0000313|EMBL:CAA20334.1}, VW02B12L.1
GN   {ECO:0000313|WormBase:VW02B12L.1};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CAA20334.1, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CAA20334.1, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CAA20334.1,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=https://doi.org/10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000313|EMBL:BAB62292.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=11441002; DOI=10.1074/jbc.M101652200;
RA   Oka T., Toyomura T., Honjo K., Wada Y., Futai M.;
RT   "Four subunit a isoforms of Caenorhabditis elegans vacuolar H+-ATPase.
RT   Cell-specific expression during development.";
RL   J. Biol. Chem. 276:33079-33085(2001).
RN   [3] {ECO:0000313|EMBL:CAA20334.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CAA20334.1};
RA   Alber B.E., Fuchs G.;
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:CAA20334.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CAA20334.1};
RG   WormBase Consortium;
RA   WormBase;
RL   Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; AB055111; BAB62292.1; -; mRNA.
DR   EMBL; BX284602; CAA20334.1; -; Genomic_DNA.
DR   PIR; T18565; T18565.
DR   RefSeq; NP_496436.1; NM_064035.6.
DR   UniGene; Cel.8017; -.
DR   IntAct; G5EGP4; 1.
DR   STRING; 6239.VW02B12L.1.1; -.
DR   TCDB; 3.A.2.2.7; the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.
DR   EnsemblMetazoa; VW02B12L.1.1; VW02B12L.1.1; WBGene00006915.
DR   EnsemblMetazoa; VW02B12L.1.2; VW02B12L.1.2; WBGene00006915.
DR   GeneID; 174743; -.
DR   KEGG; cel:CELE_VW02B12L.1; -.
DR   CTD; 174743; -.
DR   WormBase; VW02B12L.1; CE18980; WBGene00006915; vha-6.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   KO; K02154; -.
DR   OMA; MFLQPEA; -.
DR   OrthoDB; EOG091G01BI; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00006915; -.
DR   GO; GO:0045177; C:apical part of cell; IDA:WormBase.
DR   GO; GO:0016324; C:apical plasma membrane; IDA:WormBase.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IPI:WormBase.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0015986; P:ATP synthesis coupled proton transport; IBA:GO_Central.
DR   GO; GO:0002119; P:nematode larval development; IMP:WormBase.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 2.
DR   PIRSF; PIRSF001293; ATP6V0A1; 2.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001940};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Proteomics identification {ECO:0000213|EPD:G5EGP4,
KW   ECO:0000213|PeptideAtlas:G5EGP4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    412    437       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    457    475       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    555    572       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    584    607       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    693    713       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    794    818       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    121       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   865 AA;  98540 MW;  F6ED163B72FA9988 CRC64;
     MGSIYRSEHM KLCQIFFQSE SAYQCVAELG ELGMAQFIDL NEEQNAYTRK FVNEVRRCDE
     MERKINFVED EITKDLVPIP DYDEHIPAPQ PKHMGEMEAN LEKLEEELVQ INKNCKVLKN
     NHVQLLEMKA VLEHVTSLLD PHSKREAAMS ISEAARGEAG PISFGMKDEF DKPVKDEKEL
     KFVTGVVKRS KAIAFERFLW RLSRAKVFAK FIQIQEQTEL FSNEFEDKCV FILFFSGEQL
     RAKVKKICDG FQAKCYTVPE NPAERTKLLL NIKVQTTDMK AVIEKTLDYR SKCIHAAATN
     LRKWGIMLLK LKSIFHTLNM FSVDVTQKCL IAECWVPEAD IGQVKNSLHM GTIHSGSTVP
     AILNEMETDK YPPTYFKLNK FTQGFQNIVD AYGIANYREV NPAPWTIISF PFLFAVMFGD
     AGHGIIMLIA ASAFVIFEKK LISMKIKDEI FNTFFGGRYV VLLMGMFAIY TGFIYNDFYS
     KSVNIFGSSW VNPYNQTLLA NMDAQGADSN TDLSLTFPPE IAFNHDYGPY PFGVDPVWNL
     AINRLNFLNP MKMKTSILLG ISQMAFGIML SLMNHIGNRS VVDIVFVFIP QCLFLGCIFV
     YLCLQVLMKW IFFYVKPAYI FGRLYPGSNC APSLLIGLIN MFMVKSRDAS FAHDVGTAAG
     KEWVIVNGQN VTYTINDQCY LQQWYPNQSL VELILLLIAV VSVPVMLLVK PFYIRWRHSR
     GLHIDLGHGP DEHGEFNFGD IMVHQAIHTI EFVLGCVSHT ASYLRLWALS LAHAQLSDVL
     WTMVLRMSLT MGGWGGSAAI TILFYFIFSI LSVCILILME GLSAFLHAIR LHWVEFQSKF
     YGGTGIQFEP FCFTKIIRVY EGLDQ
//
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