ID G5EPG7_9MICC Unreviewed; 855 AA.
AC G5EPG7;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=ATP-dependent Clp protease ATP-binding subunit {ECO:0000313|EMBL:EHB88930.1};
GN ORFNames=HMPREF0737_00177 {ECO:0000313|EMBL:EHB88930.1};
OS Rothia mucilaginosa M508.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Rothia.
OX NCBI_TaxID=563033 {ECO:0000313|EMBL:EHB88930.1, ECO:0000313|Proteomes:UP000004897};
RN [1] {ECO:0000313|EMBL:EHB88930.1, ECO:0000313|Proteomes:UP000004897}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M508 {ECO:0000313|EMBL:EHB88930.1,
RC ECO:0000313|Proteomes:UP000004897};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A., Ward D., Feldgarden M., Gevers D., Sibley C.D., Field T.R.,
RA Grinwis M., Eshaghurshan C.S., Surette M.G., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Rothia mucilaginosa M508.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC {ECO:0000256|RuleBase:RU004432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHB88930.1}.
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DR EMBL; ACSB01000003; EHB88930.1; -; Genomic_DNA.
DR RefSeq; WP_005504372.1; NZ_JH370351.1.
DR AlphaFoldDB; G5EPG7; -.
DR PATRIC; fig|563033.4.peg.175; -.
DR HOGENOM; CLU_005070_4_1_11; -.
DR Proteomes; UP000004897; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 2.
DR Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR036628; Clp_N_dom_sf.
DR InterPro; IPR004176; Clp_R_dom.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR028299; ClpA/B_CS2.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001943; UVR_dom.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF193; CHAPERONE PROTEIN CLPB; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF02861; Clp_N; 2.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF81923; Double Clp-N motif; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51903; CLP_R; 1.
DR PROSITE; PS00870; CLPAB_1; 1.
DR PROSITE; PS00871; CLPAB_2; 1.
DR PROSITE; PS50151; UVR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000313|EMBL:EHB88930.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004432}; Protease {ECO:0000313|EMBL:EHB88930.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW ProRule:PRU01251}.
FT DOMAIN 2..144
FT /note="Clp R"
FT /evidence="ECO:0000259|PROSITE:PS51903"
FT DOMAIN 428..463
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
FT REGION 148..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 834..855
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 424..470
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 855 AA; 94022 MW; C57E58BBFE06DE6E CRC64;
MFERFTDRAR RVVVLAQEEA RMLNHNYIGT EHLLLGLIHE GEGIGARALE SLGVTLNAVR
EQVQDIVGPG PQAPNGHIPF TPRAKKVLEL SMREAIQLNH GYIGTEHILL GMVRANEGVA
NQVLVKLGAE PAAVRQAVMD LISGYPGNNS GDKETAGVGA GNSREGTPAG STILDQFGRN
LTAAAREGEL DPVIGRHKEM ERVMQVLSRR TKNNPVLIGE PGVGKTAVVE GLAQAIVHGD
VPETLKDKHL YTLDLGSLVA GSRYRGDFEE RLKKVLKEIR SRGDIILFID EIHTLVGAGA
AEGAIDAASI LKPMLARGEL QTIGATTLDE YRKHIEKDAA LERRFQPIQV EEPSQELAVQ
ILKGVRDKYE AHHRVTITDE AIETAVNLAA RYISDRFLPD KAVDLIDEAG ARLRIKRMTA
PPEIKLLDEK AAKLRQQKED AINSQDYEKA AGLRDQEQKV LAEKEEAEKA WREGGDAFGT
VTPEVIAEVL AASTGVPVYK ITEEESTRLL TMEQELHKRV IGQEHAIAAL SRAIRRTRAG
LKDPRRPGGS FIFAGPTGVG KTELAKALAE FLFGDEDSLI TLDMSEYQEK HTVSRLFGAP
PGYVGYDEGG QLTEKVRRKP FSVVLFDEVE KAHADLFNSL LQILEDGRLT DSQGRVVDFK
NTVIIMTTNL GSRDVNRRIP VGFQAMDDTA ADYERMQARV MENLKEHFRP EFLNRVDDII
VFPQLSESEI LQIVDLFVGR LAKRLAEQDM SIELTNAAKV LMAAKGYDPS MGARPLRREM
QRNIEDALSE KILFGDIKPG EKITVDVEGE GDSAKFVFSS QPMKELALDS VQELNEDAAE
APAAEAPAAE GQGND
//
