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Database: UniProt
Entry: G5F296_9ACTN
LinkDB: G5F296_9ACTN
Original site: G5F296_9ACTN 
ID   G5F296_9ACTN            Unreviewed;       505 AA.
AC   G5F296;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   08-NOV-2023, entry version 63.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|ARBA:ARBA00018893, ECO:0000256|RuleBase:RU000577};
GN   ORFNames=HMPREF1008_00490 {ECO:0000313|EMBL:EHF02845.1};
OS   Olsenella sp. oral taxon 809 str. F0356.
OC   Bacteria; Actinomycetota; Coriobacteriia; Coriobacteriales; Atopobiaceae;
OC   Olsenella.
OX   NCBI_TaxID=661087 {ECO:0000313|EMBL:EHF02845.1, ECO:0000313|Proteomes:UP000003446};
RN   [1] {ECO:0000313|EMBL:EHF02845.1, ECO:0000313|Proteomes:UP000003446}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F0356 {ECO:0000313|EMBL:EHF02845.1,
RC   ECO:0000313|Proteomes:UP000003446};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Izard J., Blanton J.M.,
RA   Baranova O.V., Tanner A.C., Dewhirst F.E., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA   Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA   Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA   Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA   Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Olsenella sp. oral taxon 809 strain F0356.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
CC       {ECO:0000256|RuleBase:RU000577}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|ARBA:ARBA00006583,
CC       ECO:0000256|RuleBase:RU004227}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EHF02845.1}.
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DR   EMBL; ACVE01000002; EHF02845.1; -; Genomic_DNA.
DR   RefSeq; WP_009278280.1; NZ_JH376563.1.
DR   AlphaFoldDB; G5F296; -.
DR   STRING; 661087.HMPREF1008_00490; -.
DR   PATRIC; fig|661087.3.peg.490; -.
DR   eggNOG; COG0593; Bacteria.
DR   HOGENOM; CLU_026910_3_1_11; -.
DR   OrthoDB; 9807019at2; -.
DR   Proteomes; UP000003446; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd00009; AAA; 1.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050; CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA; 1.
DR   PANTHER; PTHR30050:SF2; CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48295; TrpR-like; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU000577};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW   ECO:0000256|RuleBase:RU000577};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000577};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU000577};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003446}.
FT   DOMAIN          178..318
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          411..480
FT                   /note="Chromosomal replication initiator DnaA C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00760"
FT   REGION          103..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        123..140
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   505 AA;  56407 MW;  E51EFE260289EF3C CRC64;
     MDPVQESDAK VLWHDVLGLL ASKSVAPAAL AMLRSCDATA FDGSELHIAT SMGFAQRKIV
     QQTPLIEECL EQAAFQHVSL VVELLQESAP AAIQTNATVT PDELSGLAGS SGEPVAAQGQ
     DEGWQKAQRS QGRRRNNSFQ NDTSVLDSKL TFDRFVAGEE NMLAYEAAKQ VANGENKSYN
     PLFVYGKSGL GKTHLLRAIQ NYIVRNDPSR LCIYRTAGEF IEEYRIGWND DKLDARSALT
     ERYQGVDVLI IDDVQNMMTA AGTIKFFFET FNALMDRGKQ IVCAADRSPS QLGMGDSKFD
     ERETSRMDSG VTVSVQVPDY ELKLSLINTF YERMRQDAAV EHVPDLGGNI PEDMRKYMAE
     RAGTNIRIIE GFVHTCLLYA FRKERKGEAL TREDIARLAA AKWPTGQRVV TVEQIQKAVE
     SYYDVAHNDL IGSKRNKELM EPRHVAIWMT RELTDNTLAD IGKRFGGRSH ATVKHSIAWV
     DRTKKEDRLF LDRIQTLHDG ICDGG
//
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