ID G5IDB6_9CLOT Unreviewed; 1188 AA.
AC G5IDB6;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE Flags: Fragment;
GN ORFNames=HMPREF9473_01493 {ECO:0000313|EMBL:EHI60528.1};
OS Hungatella hathewayi WAL-18680.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae; Hungatella.
OX NCBI_TaxID=742737 {ECO:0000313|EMBL:EHI60528.1, ECO:0000313|Proteomes:UP000005384};
RN [1] {ECO:0000313|EMBL:EHI60528.1, ECO:0000313|Proteomes:UP000005384}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WAL-18680 {ECO:0000313|EMBL:EHI60528.1,
RC ECO:0000313|Proteomes:UP000005384};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Finegold S.M., Summanen P.H.,
RA Molitoris D.R., Song M., Daigneault M., Allen-Vercoe E., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Clostridium hathewayi WAL-18680.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHI60528.1}.
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DR EMBL; ADLN01000016; EHI60528.1; -; Genomic_DNA.
DR RefSeq; WP_006779479.1; NZ_JH379027.1.
DR AlphaFoldDB; G5IDB6; -.
DR HOGENOM; CLU_001114_3_1_9; -.
DR Proteomes; UP000005384; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF48; ATP-DEPENDENT HELICASE_NUCLEASE SUBUNIT A; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000005384}.
FT DOMAIN 1..470
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 558..868
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 22..29
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
FT NON_TER 1188
FT /evidence="ECO:0000313|EMBL:EHI60528.1"
SQ SEQUENCE 1188 AA; 133991 MW; 58D69EF30081F683 CRC64;
MNWTPEQEQV IWARNRNLLV SAAAGSGKTA VLVERIIQMV TDETNPVDID ELLVMTFTKA
AAAEMRERIG QAVERKLAEQ PDNEHLQLQS TLVHHAQITT IDSFCLNLIR DHFNVLEIDP
GFRIGDEGEL MLLRKDVMER LLEDYYEKGD ERFEQFVDTY AAGKADGGIE DYIMQVYNFA
QSNPWPMMWI ENCRKELREL EEGHLEETAW MKFLMEDVRK QLGELCEQLG NAIGICQEEG
GPEVYLPTLE TELAMLEGLR DAGTYEELCQ GLRDVSFGRL AAARSKEIDG EKKTFVTGCR
DRIKKAVAGL KENYGFEDIG EAVSDMIGTG DVVEILLELA CEFTARYQES KRDKNVVDFN
DLEHYALDVL VKQEDGKVCY TDTADELSAQ YREILVDEYQ DSNYVQEELI NSLSGARFGR
PNVFMVGDVK QSIYRFRLAR PELFMEKYET YTVEDSSCQK IELHQNFRSR ASVLESVNQV
FYSIMTKNLG NIQYTEDAAL HPGAVFEPVE QSAAGAGMVE AAGTAEDGVV PGQAVTMEDG
TVSSQVSAME ASAASDQPAM AETGTAVGQA GTPTELLLVN TGKGSGQAEG ENASRMSQAE
KDEMADYTSK EVEAKLIARR IRELTDEETG LLVWDKEEKR YRTARYRDMV ILLRSISGWT
DSFLNVLTQE GIPACADTGT GYFNTIEVET VLSILAVIDN PMQDIPLAAV FKSPVAGITD
EELAYMMALY RKNPDRGQER GLYGAWKYCM ELDIPTLSGK LHAIADFLTE MRDEAAYLPI
HEIIYRVFMK TGYYDYVSAM PAGEIRRANL DMLVEKAAAY EKTSYKGLFH FIRYINNLKK
YDTDFGEASA PGDGENMVRL MSIHKSKGLE FPIVFLAGLG KSFNKQDVRG KILIDADLGI
GTDYLNPDLR LKSTTLKKNV LKRKMDLDSL GEELRVLYVA MTRAKEKLIM TGTDRYLDKK
QEKWSQIPWE QTSIPYTVLT SAGSYLDWLL MSLPKSGKSI ITREIPLEEL VGEEVIRQVK
KQISKEELLQ MDVTTPGNRE CLDTLQSILA FRYPYEADVT LHTKMSVSEL KKLGQDADDW
DSLYQPVVPE FLREDTPASH WVSKTGQNYG ASRGTAYHRA LELLDFTTIA ARADVTTALQ
SILDNKKMEE QDWKMLDGDV IWQFLTSPLG RRMKAAQEKG LCHREQQF
//